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Role of Semaphorin 3A in Kidney Development and Diseases [PDF]
, 2023 Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse
Fukushima, Kazuhiko +5 more
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, 2021 Rare kidney diseases comprise a large group of different life-threatening or chronically debilitating disorders that affect very small numbers of people (
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Pyroptosis: A New Frontier in Kidney Diseases
Oxidative Medicine and Cellular Longevity, 2021 Pyroptosis is a pattern of programmed cell death that significantly differs from apoptosis and autophagy in terms of cell morphology and function. The process of pyroptosis is characterized predominantly by the formation of gasdermin protein family ...
Ke-jia Zhang +8 more
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Estrogen and estrogen receptors in kidney diseases
Renal Failure, 2021 Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to global health within this century. Studies have suggested that estrogen and estrogen receptors (ERs) play important roles in many physiological processes in the kidney.
Hao-Yang Ma, Shuang Chen, Yang Du
semanticscholar +1 more source
Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases
Stem cell research & therapeutics, 2021 Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and safe when used to treat kidney diseases ...
Yuling Huang, Lina Yang
semanticscholar +1 more source
Kynurenine pathway in kidney diseases
Pharmacological Reports, 2021 Kidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders the prevalence of these diseases will increase over the coming decades.
I. Zakrocka, W. Załuska
semanticscholar +1 more source
Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
Frontiers in Medicine, 2020 The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute ...
Hee-Seong Jang +3 more
semanticscholar +1 more source
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
Biomolecules, 2020 Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide, emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute kidney injury (AKI) and AKI favors CKD progression.
Miguel Fontecha-Barriuso +8 more
semanticscholar +1 more source
Roles for Exosome in Various Kidney Diseases and Disorders
Frontiers in Pharmacology, 2020 Exosome is a nanoscale vesicle with a size range of 30–100 nm. It is secreted from cell to extracellular space by exocytosis after fusion of multivesicular body (MVB) (formed by endocytic vesicles) with plasma membrane.
V. Thongboonkerd
semanticscholar +1 more source
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES COMPREHENSIVE STRATEGIC PLAN AND BUDGET TO REDUCE AND ULTIMATELY ELIMINATE HEALTH DISPARITIES [PDF]
, 2002 Many diseases and disorders that disproportionately impact the health of minority populations in the United States receive high priority in NIDDK research areas.
National Institute of Diabetes, and Digestive and Kidney Diseases
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