Results 191 to 200 of about 687,778 (313)

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Bridging the Treatment Gap in Kidney Failure Through Transplantation-A Model for Africa and Beyond. [PDF]

Transplant Direct
Muller E.
europepmc   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Blood Pressure Control in Adolescents With CKD and Risk of Kidney Failure in Young Adulthood. [PDF]

Kidney Med
Glenn DA, Botdorf M, Allen A, Dickinson K, Wieand K, Davies AG, Besser V, Dixon BP, Gluck C, Hammond J, Harshman L, Kallash M, Katsoufis C, Kibrom S, Kula A, Mitsnefes M, Miyashita Y, Modi Z, Patterson L, Denburg MR, Forrest CB, Zee J.   +21 more
europepmc   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Development and validation of deprescribing algorithms for kidney failure using consensus development methodology. [PDF]

J Pharm Policy Pract
Zidan A, Awad K, Habib S, Alsalemi N, Elgeed H, Hamad A, Al-Malki H, Alkadi M, Elesnawi M, Babiker F, Ibrahim R, Abdul Hadi M, Awaisu A.   +12 more
europepmc   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

ASN Kidney Health Guidance on Conservative Management in People with Kidney Failure. [PDF]

J Am Soc Nephrol
Wong SPY, Schell JO, Bursic AE, Butler CR, Callahan MB, Corbett C, DeGraauw J, Gazaway S, Gelfand S, Hall R, Saeed F, Scherer JS, Shaban H, Stein EJ, Weiss JW, ASN Kidney Health Workgroup on Conservative Kidney Management.   +15 more
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Feasibility and Acceptability of a Co-Designed Self-Management Programme for People Living With Kidney Failure. [PDF]

J Ren Care
Lunardi LE, Leu RKL, Bastin R, Bennett PN, Donnelly F, Borlace M, Zeng J, Myers D, Bradbrook M, Bradbrook D, Lester R, Johns E, Britton A, Jesudason S, Muthuramalingam S, Dumuid D, Matricciani LA.   +16 more
europepmc   +1 more source