Results 51 to 60 of about 5,063,263 (354)

A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure Using a Large Administrative Claims Database

ClinicoEconomics and Outcomes Research, 2021
Background To create an appropriate chronic kidney disease (CKD) management program, we developed a predictive model to identify patients in a large administrative claims database with CKD stages 3 or 4 who were at high risk for progression to kidney ...
D. Dai, Paula J. Alvarez, Steven D. Woods   +2 more
semanticscholar   +1 more source

Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing

Genome Biology, 2023
Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications.
Xin Zhang, Xinlong Wang, Jie Lv, Hongxin Huang, Jiahong Wang, Ma Zhuo, Zhihong Tan, Guanjie Huang, Jiawei Liu, Yuchen Liu, Mengrao Li, Qixiao Lin, Lian Li, Shufeng Ma, Tao Huang, Ying Lin, Xiaoyang Zhao, Zhili Rong   +17 more
doaj   +1 more source

A new outlook towards kidney injuries [PDF]

, 2012
Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Abhijeet Satwekar, Mahesh Satwekar
core   +2 more sources

SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis.

The Lancet Diabetes and Endocrinology, 2019
BACKGROUND The effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on kidney failure, particularly the need for dialysis or transplantation or death due to kidney disease, is uncertain.
B. Neuen, T. Young, H. Heerspink, B. Neal, V. Perkovic, L. Billot, K. Mahaffey, D. Charytan, D. Wheeler, Clare G. Arnott, S. Bompoint, A. Levin, M. Jardine   +12 more
semanticscholar   +1 more source

Anticoagulation in patients with kidney failure on dialysis: factor XI as a therapeutic target.

Kidney International, 2021
Chronic kidney disease (CKD) is present in almost 10% of the world population and is associated with excess mortality and morbidity. Reduced glomerular filtration rate and the presence and extent of proteinuria, key domains of CKD, have both been shown ...
J. Eikelboom, J. Floege, R. Thadhani, J. Weitz, W. Winkelmayer   +4 more
semanticscholar   +1 more source

Orange-derived and dexamethasone-encapsulated extracellular vesicles reduced proteinuria and alleviated pathological lesions in IgA nephropathy by targeting intestinal lymphocytes

Frontiers in Immunology, 2022
Current evidence highlights the critical role of the gut-kidney axis in the pathogenesis of IgA nephropathy (IgAN). However, few attempts have been made to explore targeted intestinal immunity therapy.
Wang Zhang, Ye Yuan, Xiang Li, Jiao Luo, Zhanmei Zhou, Lei Yu, Guobao Wang   +6 more
doaj   +1 more source

SOX9 inactivation affects the proliferation and differentiation of human lung organoids

Stem Cell Research & Therapy, 2021
Background The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is unknown due to a lack of ...
Lian Li, Jianqi Feng, Shanshan Zhao, Zhili Rong, Ying Lin   +4 more
doaj   +1 more source

Social and Cultural Challenges in Caring for Latinx Individuals With Kidney Failure in Urban Settings

JAMA Network Open, 2021
Key Points Question What are the perceptions of dialysis center health care professionals about the social challenges to care faced by Latinx individuals with kidney failure receiving hemodialysis? Findings This qualitative study, through interviews with
Lilia Cervantes, Katherine Rizzolo, A. Carr, J. Steiner, M. Chonchol, N. Powe, D. Cukor, R. Hasnain-Wynia   +7 more
semanticscholar   +1 more source

The Effect of Age on Performance of the Kidney Failure Risk Equation in Advanced CKD

Kidney International Reports, 2021
Introduction The Kidney Failure Risk Equation (KFRE) is a clinical tool widely used to predict progression from chronic kidney disease (CKD) to kidney failure. This study aimed to evaluate the effect of age on KFRE performance in advanced CKD. Methods We
G. Hundemer, N. Tangri, M. Sood, Edward G. Clark, M. Canney, Cedric Edwards, Christine A. White, M. Oliver, T. Ramsay, A. Akbari   +9 more
semanticscholar   +1 more source

Variety and quantity of dietary insoluble fiber intake from different sources and risk of new-onset hypertension

BMC Medicine, 2023
Background The relations of the variety and quantity of different sources of dietary insoluble fibers and hypertension remain uncertain. We aimed to investigate the associations between the variety and quantity of insoluble fibers intake from six major ...
Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Mengyi Liu, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Rui Li, Huan Li, Chengzhang Liu, Jing Nie, Fan Fan Hou, Xianhui Qin   +14 more
doaj   +1 more source