Results 71 to 80 of about 4,640,867 (405)

Acute kidney injury is associated with liver-related outcomes in patients with hepatitis B virus infection: a retrospective cohort study

BMC Nephrology
Background The effects of acute kidney injury (AKI) on liver-related outcomes in patients with hepatitis B virus (HBV) infection remain unclear. The study aimed to evaluate the association between AKI with liver-related mortality and complications in ...
Jiao Liu, Ruixuan Chen, Shiyu Zhou, Zhixin Guo, Licong Su, Lisha Cao, Yanqin Li, Xiaodong Zhang, Fan Luo, Ruqi Xu, Qi Gao, Yuxin Lin, Xin Xu, Sheng Nie, the CRDS study Investigators   +14 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury

Cell Death Discovery, 2022
Acute kidney injury (AKI) is characterized by necroinflammation formed by necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory cells and can be activated and polarized into ...
Chongbin Liu, Yanting Shen, Liuwei Huang, Jun Wang   +3 more
doaj   +1 more source

Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

Frontiers in Physiology, 2022
Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or ...
Feifei Xie, Xin Zhen, Xin Zhen, Zhuoliang Liu, Xiaomei Chen, Zhuanhua Liu, Miaomiao Zhou, Zhanmei Zhou, Zheng Hu, Fengxin Zhu, Qiaobing Huang, Lei Zhang, Jing Nie   +12 more
doaj   +1 more source

The role of zinc in renal pathological changes in diabetic status [PDF]

, 2015
Diabetes mellitus (DM) was the 8th leading cause of death in 2011, resulting in 1.4 million deaths worldwide. One of the complications of DM is chronic kidney disease, which accounts for nearly 44% of all new cases of kidney failure in the US in 2011 ...
Fernando, Julie, Zhou, Shaobo
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Kidney Failure Associates With T Cell Exhaustion and Imbalanced Follicular Helper T Cells

Frontiers in Immunology, 2020
Individuals with kidney failure are at increased risk of cardiovascular events, as well as infections and malignancies, but the associated immunological abnormalities are unclear.
S. Hartzell, Sofia Bin, Chiara Cantarelli, Meredith Haverly, J. Manrique, Andrea Angeletti, G. Manna, B. Murphy, Weijia Zhang, J. Levitsky, L. Gallon, Samuel Mon-Wei Yu, P. Cravedi   +12 more
semanticscholar   +1 more source

Chronic Kidney Disease as a Comorbidity in Heart Failure

International Journal of Molecular Sciences, 2023
Heart failure (HF) is one of the greatest problems in healthcare and it often coexists with declining renal function. The pathophysiology between the heart and the kidneys is bidirectional.
Magdalena Szlagor, Jill Dybiec, Ewelina Młynarska, J. Rysz, Beata Franczyk   +4 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source