Results 51 to 60 of about 1,919,877 (332)
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Reno-protective effects of fresh garlic against high fat diet induced damage
Hail Journal of Health Sciences, 2020 Background: Hyperlipidemia remains one of most challenging clinical problems. Garlic used to lower serum lipids in hyperlipidemia patients. The present experimental study evaluate garlic role as reno-protective against high fat diet (HFD) induced ...
Abeer Khalid Abdullah Alansari +3 more
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
مجلة علوم ذي قار, 2023 Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP ,
Hadeel Faraj, Nada Hussain Alwan
doaj +1 more source
Impact of nephrolithiasis on kidney function
BMC Nephrology, 2015 BackgroundKidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension ...
V. Sigurjonsdottir +4 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Chronic Diseases JournalBACKGROUND: The amount of impurity and addition of lead in drugs has grown increasingly. This study investigated the relationship between blood lead concentrations and kidney function tests.
Sahar Akbari-Kasgari, Iraj Javadi
doaj +1 more source
Oman Medical Journal, 2021 Objectives: Chronic kidney disease (CKD) is an independent predictor of mortality. Several creatinine-based equations are used to assess the estimated glomerular filtration rate or creatinine clearance and mortality prediction in various ethnic ...
Saif Al-Shamsi +2 more
doaj +1 more source