Results 51 to 60 of about 639,789 (302)

National temporal trend for organophosphate pesticide DDT exposure and associations with chronic kidney disease using age-adapted eGFR model

Environment International, 2022
Whilst certain environmental organochlorine pesticide exposure may still pose significant burden, the associations between dichloro-diphenyl-trichloroethane (DDT) and chronic kidney disease (CKD) remain disputable notwithstanding the potentially ...
Jia Lv, Lijuan Guo, Yue Gu, Ying Xu, Qingping Xue, Xue Yang, Qu-Nan Wang, Xiao-Ming Meng, De-Xiang Xu, Xiong-Fei Pan, Shen Xu, Yichao Huang   +11 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reference values of renal tubular function tests are dependent on age and kidney function

Physiological Reports, 2017
Electrolyte disorders due to tubular disorders are rare, and knowledge about validated clinical diagnostic tools such as tubular function tests is sparse.
Anneke P. Bech, Jack F.M. Wetzels, Tom Nijenhuis   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Relationship between Fasting Duration before Urological Surgeries and Postoperative Renal Function

مجله دانشکده پزشکی اصفهان, 2020
Background: Fasting before surgery is a necessity, but prolonged fasting can lead to serious complications such as decreased perfusion and organ dysfunction.
Kokab Basirimoghadam, Fatemeh Hosseini-Moghaddam, Mahdi Basirimoghadam, Ali Gholamzadehkafi, Huriyeh Mahyachor, Maryam Moradi   +5 more
doaj   +1 more source

Clinical and radiographic outcomes following salvage intervention for ureteropelvic junction obstruction

International Brazilian Journal of Urology, 2021
Purpose: We aimed to assess failure rates of salvage interventions and changes in split kidney function (SKF) following failed primary repair of ureteropelvic junction obstruction (UPJO).
Joseph J. Crivelli, Brett A. Johnson, Ryan L. Steinberg, Jeffrey C. Gahan, Jodi A. Antonelli, Allen F. Morey, Margaret S. Pearle, Jeffrey A. Cadeddu   +7 more
doaj   +1 more source

Do acute elevations of serum creatinine in primary care engender an increased mortality risk? [PDF]

, 2014
Background: The significant impact Acute Kidney Injury (AKI) has on patient morbidity and mortality emphasizes the need for early recognition and effective treatment.
A Bottle, A Lassnigg, A Wonnacott, AS Levey, B Talabani, Christopher KT Farmer, CY Hsu, Department of Health, EA Hoste, EM Burns, GM Chertow, Helen Hobbs, J Stewart, Jean Irving, JP Lafrance, L Gruberg, M Bedford, M Bedford, Michael Bedford, ML Praught, MM Levy, MM Schissler, Office of National Statistics, PA McCullough, Paul Bassett, Paul E Stevens, PG Metnitz, PK Li, R Bellomo, R Mehta, RL Mehta, RL Mehta, RW Schrier, S Uchino, SS Waikar, Toby Wheeler   +35 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Investigating the relationship between blood lead concentrations and kidney function tests in drug abusers admitted to Babol Hospital, Iran: A short report

Chronic Diseases Journal
BACKGROUND: The amount of impurity and addition of lead in drugs has grown increasingly. This study investigated the relationship between blood lead concentrations and kidney function tests.
Sahar Akbari-Kasgari, Iraj Javadi
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source