Results 181 to 190 of about 1,514,346 (394)

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Effects of Polyphenolic Extracts From Sumac, Pomegranate Peel, Indian Almond Leaves, Falsa, and Banana Bracts on Calcium Oxalate and Brushite Crystallization In Vitro

Chemistry &Biodiversity, EarlyView.
Polyphenolic extracts and their fractions from five plant sources inhibit calcium oxalate and brushite crystal formation in vitro, with non‐anthocyanin fractions showing stronger anti‐lithogenic effects supported by molecular docking. ABSTRACT Nephrolithiasis, or kidney stone formation, is a widespread global health concern.
Mudassir Nazir, Muhammad Abdul Haq, Syeda Moahida Batool Sherazi, Shahina Naz, Lubna Mobin, Alexandros Tsoupras   +5 more
wiley   +1 more source

New methods for the treatment of renal calculi : the St. Luke’s Hospital experience [PDF]

, 1989
The last decade has seen extraordinary advances in the management of urinary tract calculi. With the introduction of minimally invasive techniques, like percutaneus nephrolithotomy (PCN), and non-invasive ones, like extra-corporeal shock wave lithotripsy
Cutajar, L.
core  

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, EarlyView., 2023
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

A study on the effect of blue light on kidney stone formation in rats via the brain-kidney axis

Scientific Reports
Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This study aimed to investigate the effects of blue light on relevant metabolic indicators and oxidative ...
Dao-Cheng Fang, Yuan-Yuan Hu, Chao Wang, Jie Fan, Hui Wen   +4 more
doaj   +1 more source

Development of a new diagnostic device for extracorporeal shock-wave lithotripsy

, 2004
Extracorporeal Shock-Wave Lithotripsy (ESWL) is the leading technique for the non-invasive treatment of urinary stones. Thousands of ultrasound shocks are focused on the stones in order to break them into fragments small enough to be passed naturally by ...
Coleman, A.J., Fedele, F., Hurrell, A.M., Leighton, T.G., White, P.R.   +4 more
core  

Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Akbas, A, Gozuacik, D, Kosar, A, Kubilay, A, Oral, O, Sahin, O   +6 more
core  

Mono‐Ethyl‐Phosphonates: Functional Group Masking Strategy to Stabilize and Optimize the Pharmacokinetics of Rare Earth Radiochelates

ChemistryEurope, EarlyView.
Prodrug strategies are used to enhance the pharmacokinetics of small molecule drugs. Here, this approach to rare earth coordination complexes is adopted with applications as diagnostic and therapeutic radiopharmaceuticals: a mono‐ethyl‐phosphonate polyazamacrocyclic chelator for 44Sc and 177Lu reduces blood and bone uptake.
Jennifer N. Whetter, Axia Marlin, Edith K. Amason, Eduardo Aluicio‐Sarduy, Angus J. Koller, Phuong Nguyen Tran, Kaelyn V. Becker, Jonathan W. Engle, Eszter Boros   +8 more
wiley   +1 more source

Association between gout and kidney stone: results from mendelian randomization and the NHANES study

Frontiers in Genetics
BackgroundKidney stones are a common urologic disease with an increasing incidence year by year, and there are similar influences between gout status and kidney stone incidence.
Shengkai Jin, Shengkai Jin, Haochen Geng, Haochen Geng, Yichen Lu, Yichen Lu, Yuhua Zhou, Yuhua Zhou, Jing Lv, Jing Lv, Chaowei Fu, Chaowei Fu, Yuwei Zhang, Yuwei Zhang, Menglu Li, Ninghan Feng, Ninghan Feng, Ninghan Feng   +17 more
doaj   +1 more source