Results 201 to 210 of about 1,664,785 (304)

Associations of finerenone with reduced insulin resistance in patients with type 2 diabetes and chronic kidney disease: A real‐world observational study

open access: yesJournal of Diabetes Investigation, EarlyView.
This real‐world observational study enrolled 256 patients with type 2 diabetes and chronic kidney disease (T2D‐CKD). After 12 months of finerenone treatment, 45 patients completed follow‐up. Finerenone was associated with significant improvements in insulin resistance markers (HOMA‐IR, TyG index), lipid profile (LDL‐C), glycemic control (HbA1c), and ...
Xin Zhao   +4 more
wiley   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

open access: yesJournal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan   +4 more
wiley   +1 more source

Optimal Healthcare Contracts: Theory and Empirical Evidence

open access: yesJournal of Economics &Management Strategy, EarlyView.
ABSTRACT In this paper, we investigate the contracts offered by a large healthcare purchaser to health service providers. Contracts are based on the DRG principle that all hospitalizations in a diagnosis group are reimbursed at the same rate. This principle is relaxed in practice, as in several cases, the amount reimbursed within each DRG exhibits ...
Paolo Berta   +2 more
wiley   +1 more source

Lymphocystis Disease in Endemic Aotearoa New Zealand Bully (Gobiomorphus cotidianus)

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT We detected lymphocystis disease virus (LCDV) for the first time in an Aotearoa New Zealand freshwater environment, from an individual common bully, toitoi, Gobiomorphus cotidianus (Eleotridae). Dinah's bully, Gobiomorphus dinae, and Kaharore bully, Gobiomorphus mataraerore, also exhibited gross nodular lesions on the fins but were not sampled.
Kate S. Hutson   +10 more
wiley   +1 more source

Prevalence and Characteristics of Urinary Catheter Blockage in Patients With Long‐Term Urinary Catheterization: A Cross‐Sectional Study

open access: yesJournal of Clinical Nursing, EarlyView.
ABSTRACT Aims To determine the prevalence and characteristics of urinary catheter blockage in older patients using objective indicators and to characterize obstructive materials and microbiota. Design A cross‐sectional study. Methods Patients aged ≥ 65 years with an indwelling catheter for ≥ 24 h were recruited from a long‐term care hospital.
Natsumi Hirose   +11 more
wiley   +1 more source

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