Results 181 to 190 of about 1,664,785 (304)

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

open access: yesCell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang   +8 more
wiley   +1 more source

Histopathologic Characterization of Cutaneous Oxalosis Mimicking Calciphylaxis: Diagnostic Pitfalls and Polarized Light Evaluation

open access: yesJournal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous oxalosis is an uncommon manifestation of primary hyperoxalosis, which can often resemble other cutaneous manifestations of end stage renal disease (ESRD), particularly calciphylaxis. We report the case of a 46 year old female with primary hyperoxaluria type one (PH1) believed to be well‐controlled on lumasiran, a small interfering ...
Shrina Patel   +3 more
wiley   +1 more source

1173. Ipomoea pandurata (L.) G. Mey

open access: yesCurtis's Botanical Magazine, EarlyView.
Summary Ipomoea pandurata is a Morning Glory from North America which develops a large storage root. There is much uncertainty about its discovery before its formal description in the middle of the 18th century. Originally described as a Convolvulus, almost a hundred years passed before its recognition as a species of Ipomoea.
John R.I. Wood   +2 more
wiley   +1 more source

Kidney stone disease.

open access: yesTranslational andrology and urology, 2014
Chi, Thomas, Stoller, Marshall L
openaire   +4 more sources

Implementing a behavioural intervention for paediatric type 1 diabetes: Key informant perspectives of multilevel barriers and facilitators

open access: yesDiabetic Medicine, EarlyView.
Providers, healthcare leaders, adolescents and caregivers identified evidence of intervention effectiveness in lowering glycaemic levels as a key facilitator of implementing a type 1 diabetes behavioural intervention. Critical barriers to implementation include buy‐in among clinic leaders, resource availability within clinics and meeting families ...
Julia Price   +6 more
wiley   +1 more source

Effectiveness of Telehealth Low‐Carbohydrate Intervention in Preventing Chronic Kidney Disease: A Real‐World, Retrospective, Matched Cohort Study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Lifestyle interventions targeting metabolic health may influence chronic kidney disease (CKD) risk, particularly among adults with type 2 diabetes and obesity. We evaluated real‐world associations between a telehealth‐delivered, individualized nutrition therapy program (VINT) and CKD incidence and progression compared with usual ...
Shaminie J. Athinarayanan   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

open access: yesThe FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz   +13 more
wiley   +1 more source

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