Results 181 to 190 of about 53,930 (298)

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

ZJU index and the prevalence of kidney stones in US adults: evidence from NHANES 2007-2018. [PDF]

BMC Urol
Zhong S, Li G, Tian C, Ding T, Jiang M, Diao P, Gan L, Ning L.   +7 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Optimization of protein extraction and digestion workflows for proteomic analysis of saliva, salivary stones and kidney stones. [PDF]

Front Mol Biosci
Musiał N, Iwaniec M, Mruk I, Puchalski M, Tretiakow D, Skorek A, Szydłowski K, Szlęzak J, Czaplewska P.   +8 more
europepmc   +1 more source

Implementing a behavioural intervention for paediatric type 1 diabetes: Key informant perspectives of multilevel barriers and facilitators

Diabetic Medicine, EarlyView.
Providers, healthcare leaders, adolescents and caregivers identified evidence of intervention effectiveness in lowering glycaemic levels as a key facilitator of implementing a type 1 diabetes behavioural intervention. Critical barriers to implementation include buy‐in among clinic leaders, resource availability within clinics and meeting families ...
Julia Price, Janet A. Deatrick, Geoffrey Curran, Chia‐Lun Yang, Alejandra Perez Ramirez, Courtney Thomas, Anne E. Kazak   +6 more
wiley   +1 more source

Citrate and calcium kidney stones. [PDF]

Clin Kidney J
Zomorodian A, Moe OW.
europepmc   +1 more source

Empagliflozin Versus Dapagliflozin and Urogenital Adverse Events in Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Urogenital adverse events are common with sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) and may influence treatment decisions. Variations in SGLT2i selectivity, potency and effects on renal glucose excretion could lead to differences in safety profiles. We compared the risks of urinary tract infection (UTI), genital tract infection (
Christine Ljungberg, Kasper Bonnesen, Morten Schmidt, Christina Vandenbroucke‐Grauls, Michael Dalager‐Pedersen, Henrik Toft Sørensen, Mette Nørgaard, Reimar Wernich Thomsen   +7 more
wiley   +1 more source

Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones. [PDF]

Proc Natl Acad Sci U S A
Schmidt WC, Mousavi A, Li J, Yang R, Gonzalez Marin G, Schreiber HL, Hammann RES, Obernuefemann CLP, Bergeron K, Klim A, Wong D, Du K, Hultgren SJ, Chen Q, Celestian A, Wong GCL, Scotland KB.   +16 more
europepmc   +1 more source

Subgroups of Adult‐Onset Diabetes: A Prospective Follow‐Up Study of Progression of Insulin Resistance and Deficiency and Association With Liver Steatosis and Fibrosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess progression of insulin deficiency and resistance in diabetes, the stability of cluster‐based subgrouping, and the association between steatotic liver disease (SLD), liver fibrosis (LF), and tissue insulin resistance. Materials and Methods Participants from a regional diabetes register were studied within 3 years from diagnosis ...
Aleksi Laitinen, Annemari Käräjämäki, Aki J. Käräjämäki, Samu Kurki, Liisa Hakaste, Olof Asplund, Johan Hultman, Kaj Lahti, Mikko Lehtovirta, Emma Ahlqvist, Tiinamaija Tuomi   +10 more
wiley   +1 more source

Association between dietary and circulating folate markers and kidney stones in American adults: A cross-sectional NHANES analysis. [PDF]

Medicine (Baltimore)
Safargar M, Basiri A, Kord-Varkaneh H.
europepmc   +1 more source