Results 131 to 140 of about 32,146 (308)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

New rat model that phenotypically resembles autosomal recessive polycystic kidney disease [PDF]

, 2000
Numerous murine models of polycystic kidney disease (PKD) have been described. While mouse models are particularly well suited for investigating the molecular pathogenesis of PKD, rats are well established as an experimental
Dokkum, R.P.E. (Richard) van, Goedbloed, M.A. (Miriam), Guay-Woodford, L.M., Herck, H.V., Hesselink, D.A. (Dennis), Nauta, J. (Jeroen), Visser, P. (Pim), Willemsen, R. (Rob), Wright, C.J.   +8 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Protective Effects of Omega-3 Supplement Against Doxorubicin-Induced Renal Injury in Male Rats: Histopathological Study

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: Doxorubicin (DOX) is an effective chemotherapeutic agent but possesses a significant risk of inducing acute kidney injury (AKI). Unfortunately, it severely affects clinical outcomes and patient quality of life.
Ahmed Sabah Malik, Suhad Faisal Hatem, Bahir Abdul Razzaq Mshemish   +2 more
doaj   +1 more source

Time‐of‐Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins

Exploration, EarlyView.
Circadian rhythm of epoxides and its diols in the kidney and plasma showed a significant light–dark manner. Furthermore, circadian disruption by timed‐imposed of EpSA from thermo‐induced oxidized oil during the inactive phase impaired renal function. ABSTRACT Modulation of circadian rhythms impairs homeostasis, resulting in altered susceptibility to ...
Yanjun Liu, Meishan Lu, Yanpeng Du, Jie Xu, Mingjie Fan, Changhu Xue, Yuanfa Liu   +6 more
wiley   +1 more source

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

Nutritional Potential, Phytochemical Content, In Vivo Antioxidant, and Antanemic Potential of Musa paradisiaca Flower

Food Chemistry International, EarlyView.
After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo, Jethro Roland Misse Ngangue Ekwala, Somon Régine Tuem, Stéphano Tene Tambo, Merlin Ngafon Nchoutpouen, Valery Jean François Nsoga, Jules Christophe Koule Manz, Jordan Mekui Nwotue, Mathieu Ndomou   +8 more
wiley   +1 more source

Selenium‐Containing Tea‐Derived Peptides Activate Alcohol Dehydrogenase and Ameliorate Alcohol‐Induced Liver Injury by Modulating Oxidative Stress Homeostasis

Food Frontiers, EarlyView.
The graphical abstract summarizes the experimental workflow: (1) Preparation of selenium‐containing tea‐derived peptides (TSE‐PP) guided by ADH activation; (2) Purification and LC‐MS/MS identification of selenium‐modified peptides; (3) Molecular docking to reveal peptide‐ADH interactions; (4) Evaluation of hangover‐alleviating and hepatoprotective ...
Lixia Zan, Wenyi Zhang, Ning Gao, Jing Fu, Wengang Jin, Xiaoning Zhao, Xinsheng Li, Tianli Yue   +7 more
wiley   +1 more source