Results 91 to 100 of about 85,860 (310)

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core  

Expression of somatostatin receptors 3, 4, and 5 in mouse kidney proximal tubules [PDF]

, 2003
Expression of somatostatin receptors 3, 4, and 5 in mouse kidney proximal tubules.BackgroundSystemic infusion of somatostatin (SRIF) induces many physiological changes in human and rodent kidneys, including alterations in glomerular filtration, solute ...
Bates, Carlton M., Grady, Sandy, Kegg, Heather, Petrevski, Christina   +3 more
core   +1 more source

Inhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis

Cell Death and Disease, 2023
Metabolic reprogramming to glycolysis is closely associated with the development of chronic kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a rate-limiting enzyme in glycolysis, the role of the platelet isoform of ...
Shu Yang, Han Wu, Yanchun Li, Lixin Li, Jiaqing Xiang, Lin Kang, Guangyan Yang, Zhen Liang   +7 more
doaj   +1 more source

Kidney and Kidney Tumour Segmentation in CT Images [PDF]

arXiv, 2022
Automatic segmentation of kidney and kidney tumour in Computed Tomography (CT) images is essential, as it uses less time as compared to the current gold standard of manual segmentation. However, many hospitals are still reliant on manual study and segmentation of CT images by medical practitioners because of its higher accuracy.
arxiv  

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2‐Modulated Canonical Wnt/β‐Catenin Signaling

Advanced Science, 2022
Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains unknown.
Xiaobin Han, Zhongjie Sun
doaj   +1 more source

Multi‐Module Micro/Nanorobots for Biomedical and Environmental Remediation Applications

Advanced Intelligent Systems, EarlyView.
Multi‐module microrobots (MNRs) have overcome the limitations of single‐module systems by integrating components such as propeller, actuator, manipulator, and imaging modalities. They show promise in biomedical applications, such as targeted drug delivery and tissue repair, as well as in environmental remediation, including pollutant removal.
Bairong Zhu, Amar Salehi, Lei Xu, Wei Yuan, Tingting Yu   +4 more
wiley   +1 more source

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]

, 2012
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews, Bartlett, Bartlett, Bennett, Burke, C. H. J. Choi, Castanotto, Davis, Davis, de Fougerolles, de Wolf, Foglieni, Gao, H. Han, J. E. Zuckerman, Kanwar, Kanwar, Lahdenkari, M. E. Davis, Malek, Merkel, Merkel, Mishra, Ogawa, Oney, Soo Choi, Takemoto   +26 more
core   +3 more sources

Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation. [PDF]

PLoS ONE, 2014
Kidney proximal tubules subjected to hypoxia/reoxygenation develop a nonesterified fatty acid-induced energetic deficit characterized by persistent partial mitochondrial deenergization that can be prevented and reversed by citric acid cycle substrates ...
Anja Bienholz, Ahmad Al-Taweel, Nancy F Roeser, Andreas Kribben, Thorsten Feldkamp, Joel M Weinberg   +5 more
doaj   +1 more source

Cystatin C as Biomarker for the Evaluation of Renal Outcome in AL Amyloidosis

American Journal of Hematology, EarlyView.
ABSTRACT Cystatin C (CysC) has emerged as a novel and potentially more reliable biomarker for the estimation of glomerular filtration in the general population in patients with various conditions. In AL amyloidosis, the current renal staging system and renal response criteria are based on proteinuria and creatinine‐based eGFR.
Foteini Theodorakakou, Despina Fotiou, Filia Apostolakou, Ioannis Papassotiriou, Vasiliki Spiliopoulou, Ioannis Ntanasis‐Stathopoulos, Panagiotis Malandrakis, Magdalini Migkou, Nikolaos Kanellias, Evangelos Eleutherakis‐Papaiakovou, Erasmia Psimenou, Asimina Papanikolaou, Charikleia Gakiopoulou, Smaragdi Marinaki, Stavroula Giannouli, Maria Gavriatopoulou, Evangelos Terpos, Meletios‐Athanasios Dimopoulos, Efstathios Kastritis   +18 more
wiley   +1 more source