Results 141 to 150 of about 45,578 (261)

Preventive action of maleimide derivative 1-(4-Cl-benzil)-3-Cl-4-(CF3-fenilamino)-1Н-pyrrol-2,5-dion on rat’s renal system in 1,2-dimethylhydrasine-induced colon carcinogenesis

Current Issues in Pharmacy and Medical Sciences
The novel maleimide derivative 1-(4-Cl-benzil)-3-Cl-4-(CF3-fenilamino)-1Н-pirol-2,5-dion does not cause significant structure-functional changes in rats’ kidneys after 20 weeks’ daily administration.
Iryna Kharchuk, Olena Filinska, Svitlana Yablonska, Volodymyr Rybalchenko   +3 more
doaj  

Spatial transcriptomics identifies IL-32 as a lipid droplet-associated cytokine linked to tubular injury in human diabetic kidney disease. [PDF]

Inflamm Res
Meadows K, Chung H, Vo S, Imanzadeh A, Seo H, Belay SG, Swamy A, Teo W, Chapman K, Andonegui G, Benediktsson H, Stys PK, Pham T, Muruve DA, Chun J.   +14 more
europepmc   +1 more source

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

Equine Veterinary Journal, Volume 58, Issue 5, Page 1258-1268, September 2026.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira, Maria Clara Hornich Blimbliem, Anna Laura Previato Rosa Machado, Junara Bianca Rosa Abdala, Geison Morel Nogueira, Hugo Shisei Toma, Tatiane Furtado de Carvalho, Diego José Zanzarini Delfiol   +7 more
wiley   +1 more source

Potassium dichromate induces dose-dependent nephrotoxicity through oxidative stress-mediated downregulation of renal aquaporins and upregulation of KIM-1. [PDF]

Sci Rep
Shehab H, El Sayed IET, Badr EA, Anajirih N, Abdelkader A, ELwakeel EE, Ali NE, Kasem EM, Al-Shahed FAN, Zakari MO, Elmorsy EM, Ibrahim SF, Shukry M, El Nashar EM, Alshehri AM, Rawan AF, Abdeen A.   +16 more
europepmc   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Human placental extract ameliorates methotrexate-induced nephrotoxicity in albino rats: ultrastructural, biochemical and biophysical studies. [PDF]

Sci Rep
Mahran HA, Gawaan YM, El-Gerbed MS, Khedr YI.   +3 more
europepmc   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

In vivo and molecular docking investigation of the novel anti-inflammatory and mitochondrial mechanisms underlying the renoprotective effects of resmetirom and curcumin in gentamicin-induced renal toxicity in rats. [PDF]

BMC Nephrol
Ahmed AS, Sabra MS, Shaltout ES, Abdelqader ZS.   +3 more
europepmc   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Kidney-targeted drug delivery: from physiological mechanisms to precision therapeutics. [PDF]

Front Bioeng Biotechnol
Tan Z, Hu Y, Wu Y, Hu Y.
europepmc   +1 more source