Results 161 to 170 of about 85,860 (310)
Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies
Andrology, EarlyView.Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi +5 more
wiley +1 more source
Modeling the Effects of Multiple Myeloma on Kidney Function
, 2018 Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis.
Ayati, Bruce P. +2 more
core
Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.
, 2015 Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation.
Alexander, R. +6 more
core +1 more source
Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs
Artificial Organs, EarlyView.This pig model of simultaneous perfusion of paired kidneys in normothermia suggests that intra‐individual variation is relatively low, enabling one kidney to be employed as a reliable comparator of the other kidney for assessing treatments before kidney transplantation.
Margaux Navez +12 more
wiley +1 more source
Advancing antihypertensive drug development
British Journal of Pharmacology, EarlyView.Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu +5 more
wiley +1 more source
PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubulesResearch in context
EBioMedicine, 2018 Background: The renal tubules, which have distant metabolic features and functions in different segments, reabsorb >99% of approximately 180 l of water and 25,000 mmol of Na + daily.
Zhongshi Lyu +9 more
doaj
Cancer Science, EarlyView.A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka +5 more
wiley +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, EarlyView.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities
Cell Proliferation, EarlyView.ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink +4 more
wiley +1 more source