Results 251 to 260 of about 73,145 (294)
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Hydrogen transport in rabbit kidney proximal tubules--Na:H exchange
American Journal of Physiology-Renal Physiology, 1980In order to examine the cellular mechanisms of H transfer, we studied the [14C]DMO-derived cell pH in rabbit separated renal proximal tubules. Under normal conditions, cell pH (7.508 +/- 0.008, SE) was found to be more alkaline than medium pH (7.404 +/- 0.009, SE). The [14C]DMO-derived cell pH was not affected either by 10(-2) M unlabeled DMO or 10(-3)
M, Bichara +3 more
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Fluid Absorption in the Kidney Proximal Tubule
Physiology, 1987Fluid absorption in the proximal tubule can be driven by a small osmotic difference between the luminal and interstitial fluids because this leaky epithelium has a high water permeability. The osmotic difference is produced by solute absorption, which tends to dilute the luminal fluid and concentrate the interstitial fluid.
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Oxalate transport by proximal tubule of the rabbit kidney
American Journal of Physiology-Renal Physiology, 1982Oxalate transport was examined in isolated perfused segments of the proximal tubule of the rabbit. When oxalate was present in a concentration of 10(-5) M in the bathing and perfusing solutions, there was a net secretory flux of oxalate of 36.4 +/- 1.4, 34.7 +/- 4.3, and 20.7 +/- 2.8 x 10(-15) mol . min-1 .
H O, Senekjian, E J, Weinman
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Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy
American Journal of Physiology-Renal Physiology, 2021It has been established that renal proximal tubule (PT) injury is a primary cause of the development of chronic kidney disease, but the underlying molecular mechanism remains to be defined. Here, we show that cyclophilin D, a mitochondrial matrix protein, in the PT causes kidney fibrogenesis in obstructive nephropathy.
Hee-Seong Jang +4 more
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Primary Kidney Proximal Tubule Cells
2004Primary rabbit kidney epithelial cell cultures can be obtained that express renal proximal tubule functions. Toward these ends, renal proximal tubules are purified from the rabbit kidney by the method of Brendel and Meezan. To summarize, each kidney is perfused with iron oxide, which becomes associated with glomeruli.
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Energy Compartmentation and Active Transport in Proximal Kidney Tubules
1986The primary work of the kidney is active transport.1 It is a long-standing observation that a linear relationship exists between the rate of sodium reabsorption by the whole kidney and its rate of oxygen consumption.2,3 Since the oxygen is consumed at the mitochondria and the energy for active transport is used by the Na,K-ATPase located at the plasma ...
L J, Mandel, S P, Soltoff, P C, Brazy
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Metabolic heterogeneity of the proximal and distal kidney tubules
Life Sciences, 1983Proximal and distal tubule suspensions were prepared from kidneys of Sprague-Dawley rats by an isolation procedure on a Percoll gradient. The marker enzymes alkaline phosphatase (brush border) and hexokinase (cytoplasmic) as well as p-aminohippurate transport capacity, gluconeogenic activity and electron microscopy were used to characterize the two ...
C, Cojocel +4 more
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Cytosolic free calcium levels in rabbit proximal kidney tubules
American Journal of Physiology-Cell Physiology, 1982Cytosolic free Ca levels were measured in isolated rabbit proximal kidney tubules using a previously described null-point method (19). Control values for cytosolic free Ca levels averaged 0.45 +/- 0.09 microM (n = 13). Addition of 1 microM A23187, an agent expected to increase ionized Ca levels, resulted in an eightfold increase in the null point ...
E, Murphy, L J, Mandel
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Chloride distribution in the proximal convoluted tubule ofNecturus kidney
The Journal of Membrane Biology, 1981To assess the mechanism(s) by which intraluminal chloride concentration is raised above equilibrium values, intracellular Cl- activity (alpha iCl) was studied in the proximal tubule of Necturus kidney. Paired measurements of cell membrane PD (VBL) and Cl-selective electrode PD (VBLCl) were performed in single tubules, during reversible shifts of ...
A, Edelman +2 more
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Urate Transport in the Proximal Tubule of Human Kidney
1991Urate is transported bidirectionally by the renal proximal tubule of mammals. The direction of the net flux is, however, highly species dependent, so that some mammals are urate “reabsorbers” while others are urate “secreters” (Roch-Ramel and Weiner, 1980).
D, Werner, B, Guisan, F, Roch-Ramel
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