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Metabolic heterogeneity of the proximal and distal kidney tubules
Life Sciences, 1983Proximal and distal tubule suspensions were prepared from kidneys of Sprague-Dawley rats by an isolation procedure on a Percoll gradient. The marker enzymes alkaline phosphatase (brush border) and hexokinase (cytoplasmic) as well as p-aminohippurate transport capacity, gluconeogenic activity and electron microscopy were used to characterize the two ...
Jerry B. Hook +4 more
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Fluid Absorption in the Kidney Proximal Tubule
Physiology, 1987Fluid absorption in the proximal tubule can be driven by a small osmotic difference between the luminal and interstitial fluids because this leaky epithelium has a high water permeability. The osmotic difference is produced by solute absorption, which tends to dilute the luminal fluid and concentrate the interstitial fluid.
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Role of Proximal Tubules in the Pathogenesis of Kidney Disease
2011The proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located. Under normal circumstances, more than two thirds of filtered salt and water, and all filtered bicarbonate is ...
Nazih L. Nakhoul, Vecihi Batuman
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Accumulation of triglycerides in the proximal tubule of the kidney in diabetic coma
Pathology, 2003The present study was initiated by a very recent histochemical observation of lipid accumulation in the renal cortex of a woman who died in a diabetic coma. Two older reports of lipid accumulation in the kidneys of patients who died, most likely in a state of non-regulated diabetes, supported this observation.
Nielsen, H. +3 more
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Hemoglobin absorption in the proximal tubules of the kidney in the rabbit
Journal of Ultrastructure Research, 1967Relatively small quantities of hemoglobin, 1.5 mg per cubic centimeter of blood, were injected intravenously into rabbits, and ultrastructural changes in the proximal tubular epithelial cells of the kidney were followed over a 24-hour period. These experiments and prior experiments have shown that the hemoglobin is absorbed by proximal tubular cells of
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Urate Transport in the Proximal Tubule of Human Kidney
1991Urate is transported bidirectionally by the renal proximal tubule of mammals. The direction of the net flux is, however, highly species dependent, so that some mammals are urate “reabsorbers” while others are urate “secreters” (Roch-Ramel and Weiner, 1980).
Dominique Werner +2 more
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The effect of sex hormones on the proximal tubules in the rat kidney
Cell and Tissue Research, 1978The three segments (S1, S2, S3) of the proximal tubule of the rat kidney were investigated, with special reference to lysosomes, after castration, estradiol application, and at the end of pregnancy. Especially in S1 and S2 castration induces an increase of cellular autophagy.
T. H. Schiebler, K. G. Danner
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Primary Kidney Proximal Tubule Cells
2004Primary rabbit kidney epithelial cell cultures can be obtained that express renal proximal tubule functions. Toward these ends, renal proximal tubules are purified from the rabbit kidney by the method of Brendel and Meezan. To summarize, each kidney is perfused with iron oxide, which becomes associated with glomeruli.
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The ultrastructure of the developing proximal tubule in the rat kidney
Journal of Ultrastructure Research, 1975The ultrastructure of the proximal tubule cells was studied during development of the nephrons in the newborn and adult rat kidney. Cells in nonfiltering nephrons showed few cellular organelles and a large nucleus. In filtering nephrons the surface area of apical, lateral and basal cell membranes was increased in comparison to nonfiltering nephrons ...
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Contraluminal phosphate transport in the proximal tubule of the rat kidney
Pfl�gers Archiv European Journal of Physiology, 1985In order to study the characteristics of contraluminal phosphate transport the stopped flow microperfusion technique [13] has been applied. By measuring the time-dependent decrease of interstitial 33Pi concentration at different starting concentrations a simple diffusion kinetics with a permeability coefficient of 7.5 +/- 1.0 X 10(-8) cm2 s-1 was found.
Gerhard Rumrich +3 more
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