Results 71 to 80 of about 73,145 (294)

Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]

, 2018
We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie, Layton, Anita T., Vallon, Volker   +2 more
core   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

A histological study of the effect of exogenous melatonin on gentamicin induced structural alterations of proximal tubules in rats

Biomolecules & Biomedicine, 2014
The aim of this research was to assess the reactive changes of rat proximal tubules caused by gentamicin and the effect of relatively low doses of melatonin. 48 adult male Wistar rats were distributed into six groups of equal size which all received one
Dina Kapić, Zakira Mornjaković, Esad Ćosović, Maida Šahinović   +3 more
doaj   +1 more source

Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury [PDF]

, 2020
Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and ...
Basta, Jeannine, Griggs, David W, Prinsen, Michael J, Rauchman, Michael, Robbins, Lynn, Stout, Lisa   +5 more
core   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Enhancement of HGF-induced tubulogenesis by endothelial cell-derived GDNF [PDF]

, 2019
学位記番号 ...
Nakasatomi, Masao, ナカサトミ, マサオ, 中里見, 征央   +2 more
core  

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Proximal Tubular Injury in Medullary Rays Is an Early Sign of Acute Tacrolimus Nephrotoxicity

Journal of Transplantation, 2015
Tacrolimus (FK506) is one of the principal immunosuppressive agents used after solid organ transplantations to prevent allograft rejection. Chronic renal injury induced by tacrolimus is characterized by linear fibrosis in the medullary rays; however, the
Diane Cosner, Xu Zeng, Ping L. Zhang
doaj   +1 more source

Localization of retinol-binding protein messenger RNA in the rat kidney and in perinephric fat tissue.

Journal of Lipid Research, 1989
The cellular localization of retinol-binding protein (RBP) messenger RNA (mRNA) in the kidney, and the developmental pattern of the renal expression of the RBP gene, were studied in the Sprague-Dawley rat.
A Makover, D R Soprano, M L Wyatt, D S Goodman   +3 more
doaj   +1 more source

Minimal Kidney Disease Phenotype in Heterozygous Null Mice

Canadian Journal of Kidney Health and Disease, 2023
Background: Shroom family member 3 (SHROOM3) encodes an actin-associated protein that regulates epithelial morphology during development. Several genome-wide association studies (GWAS) have identified genetic variances primarily in the 5’ region of ...
Allison Lawlor, Kristina Cunanan, Joanna Cunanan, Amy Paul, Hadiseh Khalili, Doyun Ko, Ahsan Khan, Robert Gros, Thomas Drysdale, Darren Bridgewater   +9 more
doaj   +1 more source