Results 201 to 210 of about 620,224 (255)

Kidney organoids as a platform to study plasminogen-induced injury and uPA-based therapies. [PDF]

Stem Cells Transl Med
de Cos M, Yu SM, Wright J, Anandakrishnan N, Meliambro K, Wong JS, Azeloglu E, Campbell KN.   +7 more
europepmc   +1 more source

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis

The FEBS Journal, EarlyView.
In this study, we investigate how flow constrictions and shear stress trigger cardiac antibody light chain (AL) fibril formation and deposition. We mimic the mechanical forces exerted by the heart and the microvasculature network using a mini‐peristaltic pump setup and a grid‐type microchannel network, respectively.
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima, Ikuko Yumen, Ruiming He, Hirokazu Matsuda, Tetsuichi Wazawa, Takeharu Nagai, Nobuhiro Tsukada, Suguru Yamamoto, Johannes Buchner, Hirotsugu Ogi   +11 more
wiley   +1 more source

Nephrotoxic acute kidney injury induced by <i>Daboia siamensis</i> venom and its fractions: assessment of <i>Bcl-2</i> family expression in <i>in vivo</i> and <i>ex vivo</i> in rabbit models. [PDF]

J Venom Anim Toxins Incl Trop Dis
Chaiyabutr N, Suntrarachun S, Khunsap S, Khow O, Laoungbua P, Vasaruchapong T, Chanhome L, Rungsipipat A, Sitprija V.   +8 more
europepmc   +1 more source

Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB‐amplified renal cell carcinoma: a comprehensive study of 15 cases

Histopathology, EarlyView.
This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow, Melissa Y. Tjota, Jung Woo Kwon, Tatjana Antic   +3 more
wiley   +1 more source

Case Report: A case of acute kidney injury due to star fruit-infused liquor. [PDF]

Front Med (Lausanne)
Shan S, Shen M, Shi J, Liu W.
europepmc   +1 more source

HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise

HIV Medicine, EarlyView.
Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil, Nicola Wearne, Brendon Price, Frank Post, Dami A. Collier   +4 more
wiley   +1 more source

Detecting drug-induced nephrotoxicity using simultaneous label-free autofluorescence multiharmonic microscopy. [PDF]

Toxicol Sci
Alex A, Shi J, Chaney EJ, Doan M, Fisher CP, Obert L, Ishiy C, Ho A, Spillman DR, Marjanovic M, Roger J, Groseclose MR, Hood SR, Boppart SA.   +13 more
europepmc   +1 more source

Hypophosphataemia in adults: approach to diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Hypophosphataemia is a common electrolyte disorder which can have clinically significant consequences for bone, muscle, neurological and haematological function. Its causes range from transient transcellular shifts in hospitalised patients to chronic renal phosphate‐wasting disorders mediated by fibroblast growth factor 23 (FGF23).
Kajanan Parameshwaran, Mawson Wang, Kirtan Ganda   +2 more
wiley   +1 more source

S100A1 Promotes MDM2-Mediated KLF15 Ubiquitination to Regulate ID1-Driven Tubular Injury in Diabetic Kidney Disease. [PDF]

FASEB J
Zeng Z, Shang J, Chai S, Zhang X, Lv X, Han X, Xu Y, Ma B, Lv Z, Wang R.   +9 more
europepmc   +1 more source

Temporal distribution of acute kidney injury–related hospitalizations after initiation of sodium–glucose cotransporter 2 inhibitors: A nationwide claims database analysis in older adults with an independent complementary single‐center eGFR analysis

Journal of Diabetes Investigation, EarlyView.
Among 190 older adults who experienced AKI‐related hospitalization after SGLT2 inhibitor initiation, 31.1% were hospitalized within 30 days. In an independent single‐center cohort, sustained early eGFR decline was associated with older age and use of one or two triple‐whammy‐related drug classes.
Kazuya Hiura, Ayana Tatsuno, Yamato Noto, Ryosuke Wakamatsu, Masayuki Sakunami, Ryu Kobayashi, Miki Yamashita   +6 more
wiley   +1 more source