Results 41 to 50 of about 620,224 (255)

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition

Redox Biology, 2019
Transition of acute kidney injury (AKI) to chronic kidney disease (CKD) represents an important cause of kidney failure. However, how AKI is transformed into CKD remains elusive. Following folic acid injury, mice developed AKI with ensuing CKD transition,
Minglei Lu, Pei Wang, Yingjin Qiao, Chunming Jiang, Yan Ge, Bryce Flickinger, Deepak K. Malhotra, Lance D. Dworkin, Zhangsuo Liu, Rujun Gong   +9 more
doaj   +1 more source

Expression and distribution of HIF-1α, HIF-2α, VEGF, VEGFR-2 and HIMF in the kidneys of Tibetan sheep, plain sheep and goat

Folia Morphologica, 2020
BACKGROUND: The objective of this study was to detect the expression and distribution characteristics of five proteins (the hypoxia-inducible factor 1alpha [HIF-1a], HIF-2a, vascular endothelial growth factor [VEGF], VEGF-2 receptor [VEGFR-2] and hypoxia-
K. Yang, Z. Zhang, Y. Li, S. Chen, W. Chen, H. Ding, Z. Tan, Z. Ma, Z. Qiao   +8 more
doaj   +1 more source

Minimal Kidney Disease Phenotype in Heterozygous Null Mice

Canadian Journal of Kidney Health and Disease, 2023
Background: Shroom family member 3 (SHROOM3) encodes an actin-associated protein that regulates epithelial morphology during development. Several genome-wide association studies (GWAS) have identified genetic variances primarily in the 5’ region of ...
Allison Lawlor, Kristina Cunanan, Joanna Cunanan, Amy Paul, Hadiseh Khalili, Doyun Ko, Ahsan Khan, Robert Gros, Thomas Drysdale, Darren Bridgewater   +9 more
doaj   +1 more source

Studies on ion movements in Malpighian tubules of Locusta migratoria L., with particular reference to their endocrine control [PDF]

, 1990
Intracellular microelectrodes were used in conjunction with ion substitution, agonists and inhibitors of known transport processes and diuretic hormone (DH), to investigate the mechanisms whereby ions cross the basal and apical cell membranes of the ...
Fogg, Kay Elizabeth, Fogg, K.E
core  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Morfometría de cortes histológicos de los túbulos renales normales en una muestra de humanos adultos

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2017
Fundamento: los túbulos renales normales se han descrito por morfometría, lo que permite “reconstruir” en tercera dimensión la forma y el tamaño del espécimen estudiado.Objetivo: caracterizar la magnitud de los túbulos renales normales en humanos adultos,
Miosotis de Lourdes Fernández Lastre, Iraldo Mederos Pérez, Yardelys Rego Juhe, Sandor Varela Iraola, Tamara Caraballoso Recio   +4 more
doaj  

The Role of Black Soybean and Purple Sweet Potato Active Compound on Advanced Glycation End-Product in Streptozotocin-Induced Type 2 Diabetes Mellitus Rat

Journal of Tropical Life Science, 2019
Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity ...
Abdul Gofur, Siti Nur Arifah, Yuslinda Annisa, Agung Witjoro, Mochammad Fitri Atho'illah, Sri Rahayu Lestari   +5 more
doaj   +1 more source

Renal involvement in systemic lupus erythematosus: additional histopathological lesions

Archives of Medical Science, 2020
A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for ...
Monique Pereira Rêgo Muniz, Laise Pereira Arcoverde Fechine Brito, Pedro Henrique Cavalcante Vale, Felipe Leite Guedes, Thina Klicia Mendonça Oliveira, Dyego José de Araújo Brito, Natalino Salgado Filho, Márcio Dantas, Gyl Eanes Barros Silva   +8 more
doaj   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. [PDF]

PLoS Genetics, 2017
Progressive cystic kidney degeneration underlies diverse renal diseases, including the most common cause of kidney failure, autosomal dominant Polycystic Kidney Disease (PKD).
Chiara Gamberi, David R Hipfner, Marie Trudel, William D Lubell   +3 more
doaj   +1 more source