Results 61 to 70 of about 620,224 (255)

(Na+ + K+)-ATPase and plasma membrane polarity of intestinal epithelial cells : presence of a brush border antigen in the distal large intestine that is immunologically related to beta subunit [PDF]

, 1989
The previously produced monoclonal antibody IEC 1/48 against cultured rat intestinal crypt cells (Quaroni, A., and K. J. Isselbacher. 1981. J. Natl. Cancer Inst.
Quaroni, A., B Stieger, Kashgarian, M., Marxer, A., A Marxer, A Quaroni, M Kashgarian, Stieger, B., Hauri, H. P., H P Hauri   +9 more
core   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes

Redox Biology
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as ...
Inez A. Trambas, Lilliana Bowen, Vicki Thallas-Bonke, Matthew Snelson, Karly C. Sourris, Adrienne Laskowski, Michel Tauc, Isabelle Rubera, Guoping Zheng, David C.H. Harris, Phillip Kantharidis, Takahiko Shimizu, Mark E. Cooper, Sih Min Tan, Melinda T. Coughlan   +14 more
doaj   +1 more source

Knockdown of TMEM30A in renal tubular epithelial cells leads to reduced glucose absorption

BMC Nephrology, 2023
The kidney reabsorbs large amounts of glucose through Na+-glucose cotransporter 2 (SGLT2). P4-ATPase acts together with the β-subunit TMEM30A to mediate the asymmetric distribution of phosphatidylserine (PS), phosphatidylethanolamine (PE), and other ...
Sipei Chen, Xinrou Song, Qiong Xiao, Li Wang, Xianjun Zhu, Yang Zou, Guisen Li   +6 more
doaj   +1 more source

Cytosolic free calcium levels in rabbit proximal kidney tubules

, 1982
Cytosolic free Ca levels were measured in isolated rabbit proximal kidney tubules using a previously described null-point method (19). Control values for cytosolic free Ca levels averaged 0.45 +/- 0.09 microM (n = 13).
E. Murphy, L. J. Mandel
core   +1 more source

Heat-shock mediated overexpression of HNF1β mutations has differential effects on gene expression in the Xenopus pronephric kidney. [PDF]

, 2012
The transcription factor HNF1B, encoded by the TCF2 gene, plays an important role in the organogenesis of vertebrates. In humans, heterozygous mutations of HNF1B are associated with several diseases, such as pancreatic β-cell dysfunction leading to ...
Sauert, Kathrin, Gull, Mazhar, André W Brändli, Christoph Waldner, Brändli, André W., Mazhar Gull, Roose, Magdalena, Gerhart U. Ryffel (177327), Kathrin Sauert (177290), Kahnert, Stefan, Ryffel, Gerhart U., Waldner, Christoph, Kathrin Sauert, Magdalena Roose, Magdalena Roose (177306), Stefan Kahnert (177298), Gerhart U Ryffel, André W. Brändli (177322), Stefan Kahnert, Christoph Waldner (177333), Mazhar Gull (177314)   +20 more
core   +2 more sources

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Immunohistochemical determination of calbindin-d28k in the kidney of postnatal rats

Veterinární Medicína, 2004
The localization of calbindin-D28k was examined in rat kidney at different stages of development. Calbindin was found specifically in the distal convoluted tubules (DCT).
S. Timurkaan, B. G Tarakci
doaj   +1 more source

Metabolic effects of 4-pentenoate on isolated dog kidney tubules [PDF]

, 1992
Metabolic effects of 4-pentenoate on isolated dog kidney tubules. The effects of 4-pentenoate (0.01 to 10mM) were studied on suspensions of cortical tubules and of thick ascending limbs (TAL) prepared from dog kidneys.
Vinay, Patrick, Gougoux, André, Patrick Vinay, Dansereau, Danielle, Zan, Nathalie, Danielle Dansereau, André Gougoux, Nathalie Zan   +7 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source