Results 51 to 60 of about 620,224 (255)

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia ...
Mullins, A J, Edwards, Christopher R. W., Seckl, Jonathan R., Jonathan R. Seckl, Christopher R.W. Edwards, Stewart Fleming, Kotelevtsev, Yuri, John J. Mullins, Kotelevtsev, Y, Kenyon, C, Seckl, J R, Mullins, John J., Edwards, C R W, Fleming, S, Christopher Kenyon, Kenyon, Christopher, Brown, R W, Yuri Kotelevtsev, Roger W. Brown   +18 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration

Cell Reports, 2014
The mechanism and magnitude by which the mammalian kidney generates and maintains its proximal tubules, distal tubules, and collecting ducts remain controversial.
Yuval Rinkevich, Daniel T. Montoro, Humberto Contreras-Trujillo, Orit Harari-Steinberg, Aaron M. Newman, Jonathan M. Tsai, Xinhong Lim, Renee Van-Amerongen, Angela Bowman, Michael Januszyk, Oren Pleniceanu, Roel Nusse, Michael T. Longaker, Irving L. Weissman, Benjamin Dekel   +14 more
doaj   +1 more source

Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium

Cell & Bioscience, 2022
Background The kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood pressure homeostasis.
Yapei Yuan, Huan Chen, Sihua Ou, Baomei Cai, Ruifang Zhang, Yue Qin, Mengjie Pan, Shangtao Cao, Duanqing Pei, Fan Fan Hou   +9 more
doaj   +1 more source

Protective effect of resveratrol on acrylamide-induced renal impairment

Folia Morphologica, 2021
BACKGROUND: Acrylamide (ACR) has a wide range of uses. It possesses a renal impairment effect. The work aimed to study the possible protecting role of resveratrol (RVS) over the ACR-mediated renal impairment in rats.
M. M. Nasralla, S. M. Zaki, R. A. Attia
doaj   +1 more source

I hereby declare that the work presented in this document is based on research carried out by me, and that no part has previously been submitted for a degree in this or any other university [PDF]

, 1995
Inhibitors of known transport processes, in conjunction with ion substitution were used in biochemical, physiological and microelectrode studies to investigate the mechanisms underlying ion and fluid secretion across the Malpighian tubules of Locusta ...
Marshall, Sarah Louise
core  

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Study of pathological changes of kidney associated with some diseases in broilers [PDF]

Iraqi Journal of Veterinary Sciences, 2011
Seventy kidney samples of broiler chickens 3-6 weeks old were collected from private chicken farms in Mosul province, used to study gross and histopathological changes in the kidneys.
H. Kh. Ismail, M. Z. Mahmood
doaj  

Developmental studies on Malpighian tubule structure and function in Spodoptera Littoralis [PDF]

, 1993
A study has been made on Malpighian tubule structure and function in Spodoptera littoralis. The concentrations of the main ions present in insect haemolymph were determined and a Ringer solution developed on the basis of this information.
Al-Ahmadi, Saeed S.R., Al-Ahmadi, S.S
core