Results 31 to 40 of about 259,041 (316)

Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C

Brazilian Journal of Infectious Diseases, 2010
Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors.
Amal Fathy, Mohamed Mohy Eldin, Lobna Metwally, Mohamed Eida, Marwa Abdel-Rehim, Gamal Esmat   +5 more
doaj   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
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Natural killer cells in hepatitis B virus infection

Brazilian Journal of Infectious Diseases, 2015
Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection.
Shao-fei Wu, Wen-jing Wang, Yue-qiu Gao
doaj   +1 more source

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells. [PDF]

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long infection by evading clearance by the host immune system. In de novo infection and lytic replication, KSHV escapes cytotoxic T cells and NK cells through downregulation of MHC class-I ...
Nick C. Matthews, Gotch, FM, Frances M. Gotch, Robey, Rebecca C, Bower, Mark, Rebecca C. Robey, Mark Bower, Matthews, Nick C, Goodier, Martin R, Bower, M, Goodier, MR, Robey, RC, Gotch, Frances M, Martin R. Goodier, Matthews, NC   +14 more
core   +1 more source

Killer instincts: natural killer cells as multifactorial cancer immunotherapy

Frontiers in Immunology, 2023
Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of ...
Sarah Nersesian, Sarah Nersesian, Emily B. Carter, Emily B. Carter, Stacey N. Lee, Stacey N. Lee, Lauren P. Westhaver, Jeanette E. Boudreau, Jeanette E. Boudreau, Jeanette E. Boudreau   +9 more
doaj   +1 more source

Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]

, 2014
STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
Whitley, G S, Goulwara, S S, Johnstone, A P, Cartwright, JE, Whitley, GS, Goulwara, SS, Cartwright, J E, Wallace, A E, Fraser, R, Gurung, S, Wallace, AE, Johnstone, AP   +11 more
core   +1 more source

Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors

Molecular Therapy: Oncology
Although adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell trafficking and ...
Shiori Eguchi, Wen Luo, Hongwen Zhu, Jeremy M. Rosenblum, Anna R. Cooper, Mitchell S. Cairo   +5 more
doaj   +1 more source

Unraveling Natural Killer T-Cells Development

Frontiers in Immunology, 2018
Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj   +1 more source

Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT

Nature Communications, 2022
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim   +12 more
doaj   +1 more source

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
H. Kreyenberg, Gerrit Weber, S. Kloss, Bader, Peter, Koscielniak, Ewa, A. Willasch, Selim Kuci, T. Klingebiel, E. Koscielniak, Laer, Dorothee von, Miriam Stais, Willasch, Andre Manfred, D. von Laer, Klingebiel, Thomas, Klöß, Stephan, Stais, Miriam, Kuçi, Selim, Peter Bader, Eva Rettinger, Thomas Klingebiel, B. Voss, Z. Kuci, Kreyenberg, Hermann, Stephan Klöss, G. Weber, Dorothee Von Laer, E. Rettinger, Zyrafete Kuci, Kuçi, Zyrafete, Rettinger, Eva, Bernhard Voss, M. Stais, P. Bader, Hermann Kreyenberg, Weber, Gerrit, Voß, Bernhard, Ewa Koscielniak, Andre Willasch, S. Kuci   +38 more
core   +1 more source