Conservation of land plant-specific receptor-like cytoplasmic kinase subfamily XI possessing a unique kinase insert domain [PDF]
Frontiers in Plant Science, 2023 The number of genes encoding receptor-like kinases (RLKs) has expanded in the plant lineage. Their expansion has resulted in the emergence of diverse domain architectures that function in signaling cascades related to growth, development, and stress ...
Joseph Yayen +8 more
doaj +4 more sources
Association of kinase insert domain-containing receptor (KDR) gene polymorphism/ haplotypes with recurrent spontaneous abortion and genetic structure [PDF]
Iranian Journal of Reproductive Medicine, 2015 Background: Recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society.
Shiva Shahsavari +2 more
doaj +4 more sources
Kinase Insert Domain Receptor Q472H Pathogenic Germline Variant Impacts Melanoma Tumor Growth and Patient Treatment Outcomes. [PDF]
Cancers (Basel), 2023 Background: We previously reported a higher incidence of a pathogenic germline variant in the kinase insert domain receptor (KDR) in melanoma patients compared to the general population. Here, we dissect the impact of this genotype on melanoma tumor growth kinetics, tumor phenotype, and response to treatment with immune checkpoint inhibitors (ICIs) or ...
Ibrahim M +14 more
europepmc +5 more sources
Kinase insert domain receptor/vascular endothelial growth factor receptor 2 (KDR) genetic variation is associated with ovarian hyperstimulation syndrome. [PDF]
Reprod Biol Endocrinol, 2014 The objective of this investigation was to determine if kinase insert domain/vascular endothelial growth factor receptor 2 (KDR/VEGFR2) genetic variation was associated with the development of ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation (COH).This was a case-control study of 174 patients who ...
O'Brien TJ +6 more
europepmc +6 more sources
Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas. [PDF]
Oncotarget, 2016 Pituitary adenomas constitute 15-20% of intracranial neoplasms. Previously we reported that cyclin-dependent kinase 5 (CDK5) is upregulated in pituitary tumors associated with activating protein p35, and plays an essential role in pituitary adenomas progression. Here we explored the mechanisms of CDK5 signaling in prolactin pituitary adenomas. Our data
Xie W, Liu C, Wu D, Li Z, Li C, Zhang Y.
europepmc +5 more sources
Pyrrolo[3,2-d]pyrimidine derivatives as type II kinase insert domain receptor (KDR) inhibitors: CoMFA and CoMSIA studies. [PDF]
Int J Mol Sci, 2012 Kinase insert domain receptor (KDR) inhibitors have been proved to be very effective anticancer agents. Molecular docking, 3D-QSAR methods, CoMFA and CoMSIA were performed on pyrrolo[3,2-d]pyrimidine derivatives as non-ATP competitive KDR inhibitors (type II).
Wu XY +4 more
europepmc +6 more sources
Vascular Endothelial Growth Factor Gene Polymorphism (rs2010963) and Its Receptor, Kinase Insert Domain-Containing Receptor Gene Polymorphism (rs2071559), and Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus [PDF]
Journal of Diabetes Research, 2016 Background. The current study was designed to reveal possible associations between the polymorphisms of the vascular endothelial growth factor (VEGF) gene (rs2010963) and its receptor, kinase insert domain-containing receptor (KDR) gene polymorphism ...
Sebastjan Merlo +6 more
doaj +2 more sources
The -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer [PDF]
BMC Cancer, 2009 Background Kinase insert domain-containing receptor (KDR) plays a critical role in the metastasis of cancer and is used as a molecular target in cancer therapy.
Lin Jia-Ying +6 more
doaj +2 more sources
Targeting expression of the catalytic domain of the kinase insert domain receptor (KDR) in the peroxisomes ofPichia pastoris [PDF]
FEMS Yeast Research, 2009 The kinase insert domain receptor (KDR), also known as vascular endothelial growth factor receptor-2 (VEGFR2), is an important therapeutic target for the treatment of cancer because of its crucial role in angiogenesis, which is fundamental to the malignancy of tumors.
Ya Wang +9 more
openalex +3 more sources
Association of Kinase‐Insert‐Domain‐Containing Receptor Polymorphisms with Glioma Susceptibility in a Chinese Population: A Hospital‐Based Case‐Control Study [PDF]
Evidence-Based Complementary and Alternative Medicine, 2023 Background. Gliomas are the most common malignant tumors of the central nervous system. However, the inherited genetic variation in gliomas is presently unclear. Therefore, this study investigated the association of the rs2071559 and rs2239702 gene polymorphisms with glioma susceptibility in Chinese patients. Methods.
Zhi-Fa Huang +5 more
openalex +3 more sources