Results 111 to 120 of about 278,210 (335)

Overexpression of alpha‐1 antitrypsin in mesenchymal stromal cells improves their intrinsic biological properties and therapeutic effects in nonobese diabetic mice

Stem Cells Translational Medicine, 2021
Islet/β cell dysfunction and death caused by autoimmune‐mediated injuries are major features of type 1 diabetes (T1D). Mesenchymal stromal cells (MSCs) have been used for the treatment of T1D in animal models and clinical trials.
Lili Song, Wenyu Gou, Jingjing Wang, Hua Wei, Jennifer Lee, Charlie Strange, Hongjun Wang   +6 more
doaj   +1 more source

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. [PDF]

, 1990
The integrin alpha 6 beta 4 is a heterodimer predominantly expressed by epithelia. While no definite receptor function has yet been assigned to it, this integrin may mediate adhesive and/or migratory functions of epithelial cells.
Chambers, J, Cooper, HM, Quaranta, V, Reichardt, LF, Rozzo, C, Starr, L, Tamura, RN   +6 more
core   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models [PDF]

, 2023
Andrew J. Garton, Andrew P. Crew, Maryland Franklin, Andrew Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric Brown, Mark Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew O’Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An‐Hu Li, Tao Zhang, Frank C. Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, Neil W. Gibson   +28 more
openalex   +2 more sources

Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. [PDF]

PLoS ONE, 2013
To evaluate changes in endothelial progenitor cells (EPCs) and cytokines in patients with diabetic foot ulceration (DFU) in association with wound healing.We studied healthy subjects, diabetic patients not at risk of DFU, at risk of DFU and with active ...
Francesco Tecilazich, Thanh Dinh, Leena Pradhan-Nabzdyk, Ermelindo Leal, Ana Tellechea, Antonios Kafanas, Charalambos Gnardellis, Mary L Magargee, Andre Dejam, Vasilis Toxavidis, John C Tigges, Eugenia Carvalho, Thomas E Lyons, Aristidis Veves   +13 more
doaj   +1 more source

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]

, 2016
Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei, Bown, James L., Goltsov, Alexey, Harrison, David J., Mullen, Peter, Robertson, Paul, Shovman, Mark   +6 more
core   +3 more sources

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, Volume 19, Issue 4, Page 1054-1074, April 2025.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population

Journal of Human Reproductive Sciences
Background: The loss of two or more pregnancies is considered recurrent miscarriage (RM). One of the causes of this pathology is the occurrence of mutations both in pleiotropic and pathway-specific regulators and in structural genes. The simplest type of
Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova   +4 more
doaj   +1 more source

A combined synthetic-fibrin scaffold supports growth and cardiomyogenic commitment of human placental derived stem cells. [PDF]

PLoS ONE, 2012
AIMS: A potential therapy for myocardial infarction is to deliver isolated stem cells to the infarcted site. A key issue with this therapy is to have at one's disposal a suitable cell delivery system which, besides being able to support cell ...
Antonella Lisi, Enrica Briganti, Mario Ledda, Paola Losi, Settimio Grimaldi, Rodolfo Marchese, Giorgio Soldani   +6 more
doaj   +1 more source

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. [PDF]

, 2013
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly
Fujita, Masaaki, Hamada, Yoshinosuke, Kaneda, Teruya, Kawaguchi, Naomasa, Matsuura, Nariaki, Mori, Seiji, Nishikawa, Kyoko, Saegusa, Jun, Takada, Yoko K, Takada, Yoshikazu, Tran, Vu, Zhao, Min   +11 more
core   +2 more sources