Results 121 to 130 of about 276,702 (351)

Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains [PDF]

Oncogene, 1998
Signal transducers and activators of transcription (Stats) are known to transduce signals from the cell surface to the nucleus in cytokine receptor signaling. We examined the capacity of platelet-derived growth factor (PDGF) receptor to interact with and activate Stat molecules.
Lena Claesson-Welsh, Sigrídur Valgeirsdóttir, Olli Silvennoinen, Olli Silvennoinen, Carl-Henrik Heldin, Kirsi Paukku   +5 more
openaire   +3 more sources

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models [PDF]

, 2023
Andrew J. Garton, Andrew P. Crew, Maryland Franklin, Andrew Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric Brown, Mark Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew O’Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An‐Hu Li, Tao Zhang, Frank C. Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, Neil W. Gibson   +28 more
openalex   +2 more sources

Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population

Journal of Human Reproductive Sciences
Background: The loss of two or more pregnancies is considered recurrent miscarriage (RM). One of the causes of this pathology is the occurrence of mutations both in pleiotropic and pathway-specific regulators and in structural genes. The simplest type of
Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova   +4 more
doaj   +1 more source

Unexpected and durable response with regorafenib in a metastatic colorectal cancer patient without KDR mutation: A case report [PDF]

, 2018
Regorafenib is an oral multikinase inhibitor and is approved as salvage therapy in the standard treatment of advanced colorectal cancer (CRC). Due to its limited efficacy, toxicity profile, and cost, it is necessary to identify those patients who may ...
Altucci, Lucia, Bilancia, Domenico, Cifarelli, Rosa Anna, DEL GAUDIO, Nunzio, Rosati, Gerardo, Scarano, Enrico   +5 more
core   +1 more source

Stable Radical Polymers as New Electroactive Materials: Synthesis, Properties, and Emerging Applications

Advanced Functional Materials, EarlyView.
This review covers the recent advances in the synthesis and properties of stable radical polymers (SRPs) and presents their applications in electronics, magnetics, optoelectronics, and biomedicines. The review concludes with a discussion of the challenges in radical chemistry and functionalization, while shedding light on the groundbreaking potential ...
Yufeng Xiong, Yingjiang Li, Xinfang Cui, Shiwei Li, Xiangdong Peng, Yanyun Ju, Tong Zhou, Rui Feng, Yang Zhang, Zehong Wang, Qing Wang, Lijie Dong   +11 more
wiley   +1 more source

A combined synthetic-fibrin scaffold supports growth and cardiomyogenic commitment of human placental derived stem cells. [PDF]

PLoS ONE, 2012
AIMS: A potential therapy for myocardial infarction is to deliver isolated stem cells to the infarcted site. A key issue with this therapy is to have at one's disposal a suitable cell delivery system which, besides being able to support cell ...
Antonella Lisi, Enrica Briganti, Mario Ledda, Paola Losi, Settimio Grimaldi, Rodolfo Marchese, Giorgio Soldani   +6 more
doaj   +1 more source

A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo [PDF]

Cancer Research, 2004
Abstract A strategy for antagonizing vascular endothelial growth factor (VEGF) -induced angiogenesis is to inhibit the kinase activity of its receptor, kinase insert domain-containing receptor (KDR), the first committed and perhaps the last unique step in the VEGF signaling cascade.
David C. Heimbrook, William F. Hoffman, Lenora Davis, Keith W. Rickert, Brett Connolly, Elaine Rands, Susan Hill, Kathleen E. Coll, Jackson B. Gibbs, Xianzhi Mao, Stephen C. Beck, Joanne Antanavage, Kenneth A. Thomas, George D. Hartman, Laura Sepp-Lorenzino, Patrice A. Ciecko, Jennifer M. Shipman, Mark E. Fraley, Nancy E. Kohl   +18 more
openaire   +3 more sources

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. [PDF]

, 2013
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly
Fujita, Masaaki, Hamada, Yoshinosuke, Kaneda, Teruya, Kawaguchi, Naomasa, Matsuura, Nariaki, Mori, Seiji, Nishikawa, Kyoko, Saegusa, Jun, Takada, Yoko K, Takada, Yoshikazu, Tran, Vu, Zhao, Min   +11 more
core   +2 more sources

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source