Results 141 to 150 of about 276,702 (351)

Endothelial Repair in Childhood Arterial Ischaemic Stroke with Cerebral Arteriopathy

Cerebrovascular Diseases Extra, 2015
Background: We have previously shown that recurrent arterial ischaemic stroke (AIS) in children with cerebral arteriopathy is associated with increased circulating endothelial cells and endothelial microparticles, consistent with ongoing endothelial ...
Despina Eleftheriou, Vijeya Ganesan, Ying Hong, Nigel J. Klein, Paul A. Brogan   +4 more
doaj   +1 more source

Stochastic models of the binding kinetics of VEGF-A to VEGFR1 and VEGFR2 in endothelial cells [PDF]

arXiv, 2016
Vascular endothelial growth factor receptors (VEGFRs) are receptor tyrosine kinases (RTKs) that regulate proliferation, migration, angiogenesis and vascular permeability of endothelial cells. VEGFR1 and VEGFR2 bind vascular endothelial growth factors (VEGFs), inducing receptor dimerisation and activation, characterised by phosphorylation of tyrosine ...
arxiv  

Systematic Comparison of Commercial Uranyl‐Alternative Stains for Negative‐ and Positive‐Staining Transmission Electron Microscopy of Organic Specimens

Advanced Healthcare Materials, EarlyView.
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling, Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick   +4 more
wiley   +1 more source

Association of KDR rs1870377 genotype with clopidogrel resistance in patients with post percutaneous coronary intervention

Heliyon, 2021
Background: Clopidogrel is an antiplatelet therapy that is widely used in pre and post percutaneous (PCI) coronary intervention procedures to prevent platelet aggregation and stent restenosis.
Wajdy Al Awaida, Ali A. Ahmed, Asia Ali Hamza, Khalid I. Amber, Hamzeh J. Al-Ameer, Yazun Jarrar, Ghizal Fatima, Ahmed O. Maslat, Yulia Gushchina, Omar Al bawareed, Najah R. Hadi   +10 more
doaj  

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Akira Sawa, Alessandra Stangherlin, Allen, Alto, Andreas Koschinski, Anna Terrin, Anna Zoccarato, Baillie, Bailly, Biedler, Bodnar, Bombik, Carlson, Carlson, Conti, Cuschieri, Di Benedetto, Dodge, Doxsey, Feliciello, Gillingham, Gold, Gützkow, Herberg, Hinchcliffe, Houslay, Jackman, Joanne C. Mountford, Keryer, Khodjakov, Kim, Klussmann, Lamb, Lin, Lissandron, Lynch, MacKenzie, Manuela Zaccolo, Marco Mongillo, Matyakhina, McCahill, Mongillo, Mongillo, Monterisi, Nicoletta C. Surdo, Niove E. Jordanides, Puck, Raschke, Rodriguez-Collazo, Rodriguez-Collazo, Rodríguez-Vilarrupla, Schmidt, Sette, Stangherlin, Stefan, Stefania Monterisi, Stork, Takahashi, Taskén, Taylor, Taylor, Terrin, Vaasa, Walsh, Wehrens, Witczak, Wong, Zaccolo, Zaccolo, Zaccolo   +69 more
core   +2 more sources

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Double suicide genes selectively kill human umbilical vein endothelial cells

Virology Journal, 2011
Background To construct a recombinant adenovirus containing CDglyTK double suicide genes and evaluate the killing effect of the double suicide genes driven by kinase domain insert containing receptor (KDR) promoter on human umbilical vein endothelial ...
Liu Lunxu, Wang Yanping, Mei Longyong, Jia Weiguo, Che Guowei   +4 more
doaj   +1 more source

Identification of a WNT5A-Responsive Degradation Domain in the Kinesin Superfamily Protein KIF26B. [PDF]

, 2018
Noncanonical WNT pathways function independently of the β-catenin transcriptional co-activator to regulate diverse morphogenetic and pathogenic processes.
Choi, Shannon S, Cohen, Michael, Fierro, Fernando A, Ho, Hsin-Yi Henry, Hum, Jennie, Karuna, Edith P, Scales, Michael K   +6 more
core   +2 more sources

Responsive Molecules for Organic Neuromorphic Devices: Harnessing Memory Diversification

Advanced Materials, EarlyView.
Responsive molecules are essential for organic in‐sensor computing devices. This Review highlights recent advances in thedesign, synthesis, and incorporation of electrically, optically, and magnetically responsive molecules in multifunctional synaptic perception devices endowedwith both nonvolatile and volatile memory diversification. By exploiting the
Yusheng Chen, Bin Han, Marco Gobbi, Lili Hou, Paolo Samorì   +4 more
wiley   +1 more source