Results 151 to 160 of about 276,702 (351)

Effect of gene–gene and gene–environment interaction on the risk of first‐ever stroke and poststroke death

Molecular Genetics & Genomic Medicine, 2019
Background Multiple genetic and environmental factors contribute to the individual‐level heterogeneity in stroke. This study aimed to assess how the genetic interactions confer risk of stroke.
Congrui Feng, Yunyun Yang, Shujun Yang, Xin Tu, Yibo Wang, Yiqing Song, Rutai Hui, Weili Zhang   +7 more
doaj   +1 more source

Import of apocytochrome c into the mitochondrial intermembrane space along a cytochrome c1 sorting pathway [PDF]

, 1990
The question of whether cytochrome c could be functionally sorted to the mitochondrial intermembrane space along a "conservative sorting" pathway was investigated using a fusion protein termed pLc1-c. pLc1-c contains 3-fold targeting information, namely,
Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A., Wienhues, Ulla   +3 more
core  

The adaptors Grb10 and Grb14 are calmodulin-binding proteins [PDF]

, 2017
We identified the Grb7 family members, Grb10 and Grb14, as Ca2+-dependent CaM-binding proteins using Ca2+-dependent CaM-affinity chromatography as we previously did with Grb7.
Angrist, Audran, Bai, Benaim, Berchtold, Blagitko, Chin, Chu, Cooney, Dagher, Daly, Daly, Depetris, Depetris, Dey, Dong, Duval, Frantz, García-Palmero, García-Palmero, García-Palmero, Giorgetti-Peraldi, Han, Han, Hansen, He, Hoeflich, Jurado, Kairouz, Kasus-Jacobi, Laemmli, Laviola, Li, Li, Liu, Lucas-Fernández, Mano, Manser, Manser, Maqani, Margolis, Margolis, Martin-Nieto, Morrione, Morrione, Nantel, O'Neil, O'Neill, Ooi, Ramos, Reilly, San José, Shen, Shen, Stein, Tanaka, Tanaka, Tanaka, Vecchione, Vetter, Villalobo, Villarroel   +61 more
core   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors [PDF]

, 2009
Purpose Telatinib is an orally active small-molecule tyrosine kinase inhibitor of kinase insert domain receptor (KDR; VEGFR-2) and fms-related tyrosine kinase 4 (FLT4; VEGFR-3).
AD Roses, BP Schneider, D Strumberg, DM Kweekel, F Innocenti, FA Eskens, Ferry A. L. M. Eskens, G Pasqualetti, H Kariyazono, Hans Gelderblom, Henk-Jan Guchelaar, HW Park, J Pander, JJ Swen, Johan W. R. Nortier, JT Auman, Judith Wessels, L Iyer, MV Relling, N Steeghs, Natasja de Bont, Neeltje Steeghs, P Therasse, RB Diasio, S Faivre, S Purcell, SA Ridge   +26 more
core   +3 more sources

Using QCM‐D for Real‐Time Analysis of Cell Adhesion Dynamics at Biointerfaces

Advanced Materials Interfaces, EarlyView.
This study explores adhesion of human fibroblasts to functionalized biomaterial surfaces. Quartz crystal microbalance with dissipation (QCM‐D) is used to measure cell responses in real time. The QCM‐D signalis correlated with changes in cell morphology and focal adhesion kinase (FAK) activation. This data shows a positive correlation between the energy
Agnes Rogala, Hanna Tiainen, Daria Zaytseva‐Zotova   +2 more
wiley   +1 more source

Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Cell Communication and Signaling
Background Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in diabetic patients and are a key pathogenic factor for ...
Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo   +13 more
doaj   +1 more source

Mesenchymal Stem Cells and Islet Cotransplantation in Diabetic Rats: Improved Islet Graft Revascularization and Function by Human Adipose Tissue-Derived Stem Cells Preconditioned with Natural Molecules

Cell Transplantation, 2012
Hypoxia plays an important role in limiting the engraftment, survival, and function of intrahepatically transplanted islets. Mesenchymal stem cells (MSCs) were recently used in animal models of islet transplantation not only to reduce allograft rejection
Giuseppe Cavallari, Elena Olivi, Francesca Bianchi, Flavia Neri, Laura Foroni, Sabrina Valente, Gaetano La Manna, Bruno Nardo, Sergio Stefoni, Carlo Ventura   +9 more
doaj   +1 more source

Potential Role of Targeting KDR and Proteasome Inhibitors in the Therapy of Esophageal Squamous Cell Carcinoma

Technology in Cancer Research & Treatment, 2020
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types in China. In recent years, progress has been made in various types of cancer genomics including ESCC.
Ling Zhang PhD, Xia Niu MS, Yanghui Bi PhD, Heyang Cui PhD, Hongyi Li PhD, Xiaolong Cheng PhD   +5 more
doaj   +1 more source

STATUS OF A---T POLYMORPHISM IN EXON II OF KINASE INSERT DOMAIN GENE IN WOMEN WITH PREMATURE OVARIAN FAILURE

, 2018
embryogenesis, organ development, estrus, and wound healing require vascular growth and remodeling. (1,2) In addition to these beneficial processes, angiogenesis is also involved in the proliferation of disease states such as tumor growth, metastasis ...
R. Hasan, M. Sujatha
semanticscholar   +1 more source