Characterization of Vascular Endothelial Cell Growth Factor Interactions with the Kinase Insert Domain-containing Receptor Tyrosine Kinase [PDF]
Journal of Biological Chemistry, 1999 Sonia Cunningham +3 more
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Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations [PDF]
International Journal of Molecular Sciences, 2021 The kinase insert domain (KID) of RTK KIT is the key recruitment region for downstream signalling proteins. KID, studied by molecular dynamics simulations as a cleaved polypeptide and as a native domain fused to KIT, showed intrinsic disorder represented by a set of heterogeneous conformations. The accurate atomistic models showed that the helical fold
Julie Ledoux +2 more
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Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue? [PDF]
International Journal of Molecular Sciences, 2022 Receptor tyrosine kinases (RTKs) are modular membrane proteins possessing both well-folded and disordered domains acting together in ligand-induced activation and regulation of post-transduction processes that tightly couple extracellular and cytoplasmic events.
Julie Ledoux, Luba Tchertanov
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KDR (kinase insert domain receptor)/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 This is a concise review of the KDR/VEGFR2 gene, including expression, function, and implications of VEGFR2 expression in cancer.
Noah Sorrelle, Rolf A. Brekken
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An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. [PDF]
PLoS GeneticsInsulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. Multiple mechanisms are proposed for how this altered signaling slows aging.
Marc Tatar +7 more
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Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. [PDF]
The EMBO Journal, 1992 Efficient binding of active phosphatidylinositol (PI) 3'-kinase to the autophosphorylated macrophage colony stimulating factor receptor (CSF-1R) requires the noncatalytic kinase insert (KI) region of the receptor. To test whether this region could function independently to bind PI 3'-kinase, the isolated CSF-1R KI was expressed in Escherichia coli, and
Michael Reedijk +6 more
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World Journal of Gastroenterology, 2005 To evaluate the killing effect of double suicide gene mediated by adenovirus and regulated under kinase domain insert containing receptor (KDR) promoter on human umbilical vein endothelial cells.By PCR technology, human KDR promoter gene, Escherichia coli (E. coli) cytosine deaminase (CD) gene and the herpes simple virus-thymidine kinase (TK) gene were
Zong-hai Huang
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Double suicide genes driven by kinase domain insert containing receptor promoter selectively kill human lung cancer cells [PDF]
Genetic Vaccines and Therapy, 2011 Abstract Background To investigate the selective killing efficacy of the double suicide genes driven by KDR promoter. Materials and methods A double suicide gene system with the KDR promoter, pcDNA3-KDRp-CDglyTK, was constructed and transfected into lung cancer cell lines ...
Junrong Ma +6 more
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Genetics and Molecular Research, 2015 We investigated the effects of kinase insert domain receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to erlotinib. A KDR small interfering RNA (siRNA) sequence was designed and synthesized; then, it was transfected into A549 cells using Lipofectamine(TM) 2000.
Wenya Zhu, Yashuang Liu
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Transactivation of Fetal Liver Kinase-1/Kinase-Insert Domain-Containing Receptor by Lysophosphatidylcholine Induces Vascular Endothelial Cell Proliferation [PDF]
Endocrinology, 2005 Lysophosphatidylcholine (LPC), a major lipid component of oxidized low-density lipoprotein, is a bioactive lipid molecule involved in numerous biological processes including the progression of atherosclerosis. Recently orphan G protein-coupled receptors were identified as high-affinity receptors for LPC.
Yoshiko Fujita +8 more
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