Results 241 to 250 of about 276,702 (351)

Exploring the Therapeutic Potentials and Molecular Mechanisms of Coscinium fenestratum Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach. [PDF]

Prev Nutr Food Sci
Park JW, Rarison RHG, Truong VL, Jeong WS.   +3 more
europepmc   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair. [PDF]

Int Wound J
Nahm WJ, Falanga V.
europepmc   +1 more source

Highly Loaded Reactive Oxygen Species–Responsive Theranostic Lenvatinib‐Prodrug Nanoparticles Produced by Dispersion Polymerization

Advanced NanoBiomed Research, EarlyView.
A kinase inhibitor prodrug monomer is designed with a polymerizable imidazole moiety, enabling its copolymerization with imidazole into particles containing up to 90 wt% prodrug. These particles also exhibit activity for photoacoustic imaging. Upon exposure to reactive oxygen species, the promoiety undergoes scission, releasing the native kinase ...
Sarah Spiewok, Felicitas Jansen, Jiaying Han, Markus Lamla, Max von Delius, Christian Trautwein, Laura De Laporte, Alexander J. C. Kuehne   +7 more
wiley   +1 more source

Immunoengineering of a Photocaged 5´‐triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG‐I Activation in Cancer

Angewandte Chemie International Edition, EarlyView.
This study presents a method for precise control of RIG‐I (retinoic acid inducible gene I), an innate immune receptor of RNA that, when activated, induces anti‐tumor immune responses and cancer cell death. By incorporating photocage modifications into RNA ligands, we enable a spatially and temporally regulated immune response and offer a targeted ...
Sandra Anika Lewash, Vivien Rose McKenney, Christine Wuebben, Janos Ludwig, Racha Hosni, Dirk Radzey, Marieta I. Toma, Eva Bartok, Martin Schlee, Thomas Zillinger, Alexander Heckel, Gunther Hartmann   +11 more
wiley   +1 more source

Correction: Exploring the potential of contrast agents in breast cancer echography: current state and future directions. [PDF]

J Ultrasound
Monzeglio O, Melissa VM, Rodolfi S, Valentini E, Carriero A.   +4 more
europepmc   +1 more source

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie International Edition, Accepted Article.
The interaction between the microtubule associated protein Tau and the tyrosine kinase Fyn is believed to play a pivotal role in the early stage of Alzheimer’s disease (AD). Previous studies have identified the SRC Homology 3 (SH3) domain of Fyn as the binding receptor of several proline‐rich motifs in Tau.
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D’Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +1 more source

RNA‐Based Biopesticides: Pioneering Precision Solutions for Sustainable Aquaculture in China

Animal Research and One Health, EarlyView.
The Chinese dragon represents RNA biopesticides, which effectively counteract bacterial, viral, and parasitic threats, safeguarding aquatic life. This method is precise, focusing solely on harmful agents and sparing beneficial aquaculture species. Its innovative nature protects aquatic environments while reducing ecological footprint.
Yiran Huang, Yingmin Dai, Zhuotong Huang, Mengqi Zhang, Lijun Xiu, Xianhui Zhang, Youyu Zhang, Lixing Huang   +7 more
wiley   +1 more source

Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Endogenous retroelements (EREs) stimulate type 1 interferon (IFN‐I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN‐I levels are increased.
Faye A. H. Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G. Pratt, Ben Barron‐Millar, Amy E. Anderson, Catharien M. U. Hilkens, John Casement, Vincent Bondet, Darragh Duffy, Fan Zhang, Ruchi Shukla, John D. Isaacs   +12 more
wiley   +1 more source

Vascular Endothelial Growth Factor Receptors in the Vascularization of Pancreatic Tumors: Implications for Prognosis and Therapy. [PDF]

Curr Issues Mol Biol
Grobbelaar C, Steenkamp V, Mabeta P.
europepmc   +1 more source