Results 271 to 280 of about 276,702 (351)

Computational Cellular Mathematical Model Aids Understanding the cGAS-STING in NSCLC Pathogenicity. [PDF]

Bio Protoc
Khandibharad S, Gulhane P, Singh S.
europepmc   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

ChemElectroChem, EarlyView.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský, Natália Košútová, Lenka Lorencová, Peter Kasák, Tomáš Bertók, Ján Tkáč   +5 more
wiley   +1 more source

The Development of Selective Chemical Probes for Serine Arginine Protein Kinase 3. [PDF]

Chem Biol Drug Des
Hanke D, McCutcheon C, Page BDG.
europepmc   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, EarlyView.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Caveolin-3: therapeutic target for diabetic myocardial ischemia/reperfusion injury. [PDF]

Mol Med
Wen X, Ji Y, Tang H, Jin Z, Su W, Zhou L, Xia ZY, Li L, Lei S.   +8 more
europepmc   +1 more source

Tristetraprolin affects invasion‐associated genes expression and cell motility in triple‐negative breast cancer model

Cytoskeleton, EarlyView.
Abstract Tristetraprolin (TTP) is an RNA‐binding protein that negatively regulates its target mRNAs and has been shown to inhibit tumor progression and invasion. Tumor invasion requires precise regulation of cytoskeletal components, and dysregulation of cytoskeleton‐associated genes can significantly alter cell motility and invasive capability. Several
Anastasiia Hubiernatorova, Josef Novak, Michaela Vaskovicova, David Sekac, Serhii Kropyvko, Zdenek Hodny   +5 more
wiley   +1 more source

Modulation of plant growth and development through altered ethylene binding affinity of the ethylene receptor ETR1. [PDF]

BMC Plant Biol
Aman S, Swain S, Dutta E, Abbas S, Li N, Shakeel SN, Binder BM, Schaller GE.   +7 more
europepmc   +1 more source

Phase II study evaluating the safety and efficacy of neratinib and trastuzumab biosimilar in patients with HER2 mutated advanced solid tumors: KCSG AL20‐17/KM23 trial

Cancer Communications, EarlyView.
Kyoungmin Lee, Kyung‐Hun Lee, Dong‐Wan Kim, Jeesun Yoon, Yoon Ji Choi, Soohyeon Lee, Ju Won Kim, Kyong Hwa Park, Wonyoung Choi, Youngjoo Lee, Hyewon Ryu, Dong‐Hoe Koo, YunGyoo Lee, Hei‐Cheul Jeung, Min‐Young Lee, Namsu Lee, Myoung Joo Kang, Jieun Lee, Sook Hee Hong, Eun Joo Kang, In Hae Park   +20 more
wiley   +1 more source

GDF15 Analogues Acting as GFRAL Ligands

ChemMedChem, EarlyView.
Considering the great importance of the GDF15/GRAL/RET signalling pathway, this review focuses on GDF15‐derived analogues able to act either as GFRAL agonists or antagonists, investigating their possible pharmacological applications in the treatment of GDF15‐related conditions, such as obesity and diabetes (agonist), or cancer‐induced nausea and ...
Andrea Di Santo, Livio Tarchi, Gianluca Villa, Giovanni Castellini, Valdo Ricca, Roberta Squecco, Anna Maria Papini, Feliciana Real‐Fernandez, Paolo Rovero   +8 more
wiley   +1 more source

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor. [PDF]

Proc Natl Acad Sci U S A
Husremović T, Meier V, Piëch L, Siess KM, Antonioli S, Grishkovskaya I, Kircheva N, Angelova SE, Wenzl K, Brandstätter A, Veis J, Miočić-Stošić F, Anrather D, Hartl M, Truebestein L, Cerron-Alvan LM, Leeb M, Žagrović B, Hann S, Bock C, Ogris E, Dudev T, Irwin NAT, Haselbach D, Leonard TA.   +24 more
europepmc   +1 more source