Results 21 to 30 of about 32,949 (273)

Bioinformatics analysis identifies key genes of prognostic value in lung cancer [PDF]

Journal of Men's Health, 2023
Lung cancer is the most common human malignancy worldwide and can be divided into different types of carcinomas depending on their pathological features.
Dan Song, Li Sun
doaj   +1 more source

The kinase insert domain of colony stimulating factor‐1 receptor is dispensable for CSF‐1 induced phosphatidylcholine hydrolysis [PDF]

FEBS Letters, 1991
Mouse NIH 3T3 fibroblasts transfected with human colony stimulating factor‐1 receptor produced diacylglycerol in response to CSFI and this correlated with elevated phosphatidylcholine hydrolyzing activity measured in an in vitro assay. Treatment of cells with the isoflavone derivative genistein attenuated PC hydrolysis in vitro suggesting a role for ...
Goutam Ghosh Choudhury, Victor L. Sylvia, Ling-Mei Wang, J.E. Pierce, Alan Y. Sakaguchi   +4 more
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Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function

Frontiers in Endocrinology, 2021
Mutations of the insulin-like receptor in Drosophila extend lifespan. New research suggests this receptor operates in two modes. The first extends lifespan while slowing reproduction and reducing growth.
Marc Tatar
doaj   +1 more source

Kinase domain insert containing receptor promoter controlled suicide gene system selectively kills human umbilical vein endothelial cells

World Journal of Gastroenterology, 2006
To study the selective killing of human umbilical vein endothelial cells (HUVECs) by a double suicide gene under the regulation of a kinase domain insert containing receptor (KDR) promoter and mediated by an adenoviral gene vector.Human KDR promoter was cloned by polymerase chain reaction (PCR), and two recombinant adenoviral plasmids pAdKDR-CdglyTK ...
Wenyu Yang
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Data from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

, 2023
<div>Abstract<p>OSI-930 is a novel inhibitor of the receptor tyrosine kinases Kit and kinase insert domain receptor (KDR), which is currently being evaluated in clinical studies. OSI-930 selectively inhibits Kit and KDR with similar potency in intact cells and also inhibits these targets <i>in vivo</i> following oral dosing.
Andrew J. Garton, Andrew P. Crew, Maryland Franklin, Andrew Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric Brown, Mark Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew J. O’Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An‐Hu Li, Tao Zhang, Frank C. Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, Neil W. Gibson   +28 more
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Endothelial Cell-specific Chemotaxis Receptor (ECSCR) Enhances Vascular Endothelial Growth Factor (VEGF) Receptor-2/Kinase Insert Domain Receptor (KDR) Activation and Promotes Proteolysis of Internalized KDR [PDF]

Journal of Biological Chemistry, 2013
The endothelial cell-specific chemotaxis receptor (ECSCR) is a cell-surface protein selectively expressed by endothelial cells (ECs), with roles in EC migration, apoptosis and proliferation. Our previous study (Verma, A., Bhattacharya, R., Remadevi, I., Li, K., Pramanik, K., Samant, G. V., Horswill, M., Chun, C. Z., Zhao, B., Wang, E., Miao, R.
Sreenivasulu Kilari, Indulekha Remadevi, Baofeng Zhao, Jing Pan, Qing Miao, Ramani Ramchandran, Paula E. North, Ming You, Nader Rahimi, George A. Wilkinson   +9 more
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Vascular Endothelial Cell Growth Factor-Driven Endothelial Tube Formation Is Mediated by Vascular Endothelial Cell Growth Factor Receptor-2, a Kinase Insert Domain-Containing Receptor [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract — Vascular endothelial cell growth factor (VEGF) binds to 2 related receptor tyrosine kinases, known as kinase insert domain-containing receptor (KDR) and fms -like tyrosine kinase ...
Suya Yang, Xiaohua Xin, Constance Zlot, Gladys S. Ingle, Germaine Fuh, Bing Li, Barbara Moffat, Abraham M. de Vos, Mary E. Gerritsen   +8 more
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Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. [PDF]

Molecular and Cellular Biology, 1991
A phosphatidylinositol-3 (PI-3) kinase activity of unknown biological function associates with tyrosine kinase-containing proteins, including a number of growth factor receptors after ligand stimulation. In the beta platelet-derived growth factor (beta PDGF) receptor, phosphorylation of a specific tyrosine residue within the kinase insert domain was ...
JiaDe Yu, Mohammad A. Heidaran, Jacalyn H. Pierce, J. Silvio Gutkind, Donald P. Lombardi, Marco Ruggiero, S A Aaronson   +6 more
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Functional characterization and development of novel human kinase insert domain receptor chimeric antigen receptor T-cells for immunotherapy of non-small cell lung cancer

European Journal of Pharmaceutical Sciences, 2022
CAR-T cell therapy, in which T cells are transfected or transduced with a chimeric antigen receptor (CAR), is a transformative type of cancer immunotherapy. Despite outstanding success in hematological malignancies, their efficacy against solid tumors has been limited.
Ming Zhong, Ghanbar Mahmoodi Chalbatani, Meifang Deng, Qiuyi Li, Elahe Gharagouzloo, Michael R. Hamblin, Eloah Rabello Suarez, Lili Hu, Dingding Wang   +8 more
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Kinase Insert Domain Receptor (KDR) Extracellular Immunoglobulin-like Domains 4–7 Contain Structural Features That Block Receptor Dimerization and Vascular Endothelial Growth Factor-induced Signaling [PDF]

Journal of Biological Chemistry, 2001
The vascular endothelial growth factor (VEGF) receptor tyrosine kinase subtype kinase insert domain receptor (KDR) contains seven extracellular Ig-like domains, of which the three most amino-terminal contain the necessary structural features required for VEGF binding.
Qi Tao, Marina V. Backer, Joseph M. Backer, Bruce I. Terman   +3 more
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