Results 311 to 320 of about 276,702 (351)

The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-->q12.

Cytogenetic and Genome Research, 1995
Through in situ hybridization of a genomic DNA probe to metaphase chromosomes, we have localized the KDR gene to 4q11-->q12. This is the same locus as that for two other receptor tyrosine kinases, PDGFRA and KIT.
Sheila N.J. Sait, M. Dougher-Vermazen, T. Shows, B. I. Terman   +3 more
semanticscholar   +4 more sources

Kinase insert domain-containing receptor kinase inhibitors as anti-angiogenic agents

Expert Opinion on Investigational Drugs, 2002
A variety of data accumulated during the past 10 years indicates that vascular endothelial growth factor-mediated angiogenesis is a key process in the growth of solid tumours. Efficacious and specific modulation of that signalling event through the inhibition of the cognate tyrosine kinase kinase insert domain-containing receptor (Flk-1) has been ...
G. Hartman, M. Fraley, M. Bilodeau
semanticscholar   +4 more sources

Association of kinase insert domain receptor (KDR -604, 1192, and 1719) polymorphisms with cerebral white matter lesions

Genes & Genomics, 2012
Kinase insert domain receptor (KDR) gene polymorphisms are associated with coronary artery lesions. The aims of this study were to evaluate the role of KDR polymorphisms in patients susceptible to cerebral white matter lesion (cWML), and determine the relationship between KDR polymorphisms and plasma total homocysteine levels.
Su Yeoun Kim, Y. Jeon, Seung-Hun Oh, Hyun Sook Kim, O. Kim, D. Oh, Mingull Jeung, B. Shin, Young Seok Park, N. Kim   +9 more
semanticscholar   +4 more sources

Association between kinase insert domain-containing receptor polymorphisms (−604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women

Menopause, 2012
The aim of the study was to investigate whether the -604T>C, 1192G>A, and 1719A>T polymorphisms in the kinase insert domain-containing receptor (KDR) gene confer risk for premature ovarian failure (POF) in Korean women.DNA samples from 133 POF patients and 230 controls were genotyped for the three KDR single nucleotide polymorphisms by polymerase chain
H. Rah, Y. Jeon, Youngsok Choi, S. Shim, J. Ko, T. Yoon, S. Cha, N. Kim   +7 more
semanticscholar   +4 more sources

1206Endothelial cell-specific deletion of vascular endothelial growth factor receptor 2/kinase insert domain protein receptor and proliferative pulmonary vasculopathy

European Heart Journal, 2018
M. Winter, S. Smriti, J. Altmann, Seidl, A. Alimohammadi, B. Redwan, F. Nagel, D. Santer, B. Podesser, S. Sibilia, T. Helbich, G. Prager, A. Ilhan-Mutlu, M. Preusser, I. Lang   +14 more
semanticscholar   +3 more sources

The Kinase Insert Domain-containing Receptor (KDR) is Regulated by Shear Stress

Scandinavian Cardiovascular Journal, 2002
Intimal hyperplasia develops in areas with low shear stress. The aim of the present study was to investigate if the mRNA expression of vascular endothelial growth factor (VEGF), Fms-like tyrosine kinase-1 receptor (Flt-1) and kinase insert domain-containing receptor (KDR) is regulated by shear stress.Endothelial cells from human umbilical veins were in
T Staalesen, Bo Risberg, E Mattsson
openaire   +3 more sources

Genetic Variations of Kinase Inserts Domain Receptor (KDR) Gene Are Associated with the Risk of Astrocytomas

Molecular Neurobiology, 2015
Astrocytomas is one of the most common central nervous system (CNS) tumors with high mortality rate. Kinase insert domain receptor (KDR) is involved in the regulation of tumor angiogenesis, migration, and vascular permeability. The aim of the study was to explore the relationship between KDR polymorphisms and risk of astrocytomas.
Yufei Gao, Yan Liu, Yichun He, Yang Jiang, Piyong Ma   +4 more
openaire   +3 more sources

Association between kinase insert domain-containing receptor gene polymorphism and haplotypes and ischemic stroke

Journal of the Neurological Sciences, 2011
Kinase insert domain-containing receptor (KDR), a type 2 vascular endothelial growth factor receptor, plays a crucial role in angiogenesis and vascular integrity of blood vessels. We evaluated whether single nucleotide polymorphisms (SNPs) and haplotype of kinase insert domain-containing receptor (KDR) are associated with increased risk of ischemic ...
Kyung-Tae Min, Hyun Sook Kim, Won-Chan Kim, Young Joo Jeon, Nam Keun Kim, Seung-Hun Oh, Ju-Sun Moon, Ok Joon Kim, Mi-Hwa Kim, Eunkyung Park   +9 more
openaire   +3 more sources

The kinase insert domain-containing receptor is an angiogenesis-associated antigen recognized by human cytotoxic T lymphocytes

Blood, 2006
Antigen-specific cancer immunotherapy directed toward tumor-nourishing angiogenic blood vessels holds the promise of high efficacy, low toxicity, and ease of application. To evaluate whether the human angiogenic kinase insert domain-containing receptor (KDR) can serve as a target for cellular immunotherapy, 19 peptide sequences with HLA-A*0201 motifs ...
Dirk Schadendorf, Yuansheng Sun, C. James Kirkpatrick, Mingxia Song, Astrid Schwantes, Klaus Cichutek, Stefan Stevanovic   +6 more
openaire   +3 more sources

Association between kinase insert domain-containing receptor gene polymorphisms and silent brain infarction: A Korean study

Journal of the Neurological Sciences, 2012
Kinase insert domain-containing receptor (KDR), vascular endothelial growth factor receptor-2, play a pivotal role in endothelial dysfunction, which may lead to silent brain infarction (SBI). We evaluated whether single nucleotide polymorphisms (SNPs) of KDR genes are associated with increased risk of SBI in a Korean population.A total of 383 patients ...
Inbo Han, Hyun Seok Kim, Yunkyung Cho, Yang D. Teng, Nam Keun Kim, Ok Joon Kim, Alexander E. Ropper   +6 more
openaire   +3 more sources