Results 321 to 330 of about 276,702 (351)

A Divalent Metal Ion Binding Site in the Kinase Insert Domain of the .alpha.-Platelet-Derived Growth Factor Receptor Regulates Its Association with SH2 Domains

Biochemistry, 1995
To investigate the effects of metal ion binding to the alpha-PDGFR kinase insert domain, a PCR product representing amino acid residues 691-795 (104 amino acids) was bacterially expressed and purified. Secondary structure prediction and circular dichroism spectroscopy indicated this domain to be a mixed alpha + beta protein with a large coil/turn ...
Peter McPhie, Eugenio Santos, Narmada Thanki, M. A. Heidaran, Jin Chen Yu, Daruka Mahadevan, Pilar Aroca, John F. Beeler, Alexander Wlodawer   +8 more
openaire   +3 more sources

Generation of Gene-Modified T Cells Reactive against the Angiogenic Kinase Insert Domain-Containing Receptor (KDR) Found on Tumor Vasculature

Human Gene Therapy, 2000
The destruction of newly forming tumor vasculature is a promising approach to inhibit tumor growth. The goal of the present study was to investigate whether human lymphocytes gene modified to express a chimeric receptor specific for the angiogenic endothelial cell receptor, KDR, could react against KDR(+) cells.
Zhenping Zhu, Jennifer A. Westwood, Patrick Hwu, Michael H. Kershaw, Steven K. Libutti, Larry Witte   +5 more
openaire   +3 more sources

INDUCTION OF CYP1A IN THE BEAGLE DOG BY AN INHIBITOR OF KINASE INSERT DOMAIN-CONTAINING RECEPTOR: DIFFERENTIAL EFFECTS IN VITRO AND IN VIVO ON MRNA AND FUNCTIONAL ACTIVITY

Drug Metabolism and Disposition, 2005
Compound I [3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one] is a potent inhibitor of human kinase insert domain-containing receptor (KDR kinase), which is under investigation for the treatment of cancer. Bile duct-cannulated male beagle dogs were administered 6 mg/kg compound I q.d. for 14 days.
Karen Richards, Cheri M. Brown, Aimee Michael, Catherine Boothe-Genthe, Conrad E. Raab, Raju Subramanian, Mona Parikh, Charles C. Lin, Thomas H. Rushmore, Minh Luu, Patrice Ciecko, Christopher R. Gibson, Kimberly Michel, Paul Krolikowski, Jennifer K. Adelsberger, A. David Rodrigues, Rominder Singh, Janice Brunner, Edward J. Carlini, Thomas A. Baillie   +19 more
openaire   +3 more sources

[Expression of kinase insert domain-containing receptor in prostate adenocarcinoma].

Zhonghua nan ke xue = National journal of andrology, 2007
To investigate the correlation between the expression of the kinase insert domain-containing receptor (KDR) and the histological grade of prostate adenocarcinoma.Forty-eight samples of prostate adenocarcinoma tissues and 20 samples of benign prostatic hypertrophy (BPH) tissues were studied by LsAB immunohistochemical staining.The positive expression ...
An-sheng, Bai, Hao, Zeng, Xiang, Li, Qiang, Wei, Hong, Li, Yu-ru, Yang   +5 more
openaire   +1 more source

Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody

Cancer Letters, 1999
The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential for tumor growth and metastasis. Here
Angel Santiago, Peter Bohlen, Tim Simcox, Larry Witte, Dan Lu, Zhenping Zhu, Helen Kotanides, Xenia Jimenez, Daniel J. Hicklin   +8 more
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Molecular docking and 3D-QSAR study on 4-(1H-indazol-4-yl) phenylamino and aminopyrazolopyridine urea derivatives as kinase insert domain receptor (KDR) inhibitors

Journal of Molecular Modeling, 2012
Xiaoyun Wu, Shuguang Wu, Wen-Hua Chen
semanticscholar   +1 more source

A review of cancer immunotherapy toxicity

Ca-A Cancer Journal for Clinicians, 2020
Lucy Boyce Kennedy
exaly