Journal of Food and Drug Analysis, 2015 A quantitative structure-activity relationship (QSAR) study was performed on a set of amino-substituted nitrogen heterocyclic urea derivatives. Two novel approaches were applied: (1) the simplified molecular input-line entry systems (SMILES) based optimal descriptors approach; and (2) the fragment-based simplex representation of molecular structure ...
Hayriye Yilmaz +7 more
openalex +5 more sources
Bioinformatics analysis identifies key genes of prognostic value in lung cancer [PDF]
Journal of Men's Health, 2023 Lung cancer is the most common human malignancy worldwide and can be divided into different types of carcinomas depending on their pathological features.
Dan Song, Li Sun
doaj +1 more source
Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function
Frontiers in Endocrinology, 2021 Mutations of the insulin-like receptor in Drosophila extend lifespan. New research suggests this receptor operates in two modes. The first extends lifespan while slowing reproduction and reducing growth.
Marc Tatar
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BMC Nephrology, 2022 Background Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically determined. Herein, we focused on
Yue Qian +15 more
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Resolving the binding-kinase discrepancy in bacterial chemotaxis: A nonequilibrium allosteric model and the role of energy dissipation [PDF]
Proc. Natl. Acad. Sci. U.S.A. 120, e2303115120 (2023), 2023 The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the extracellular ligand concentration and adapt across a wide concentration range by undergoing methylation and ...
arxiv +1 more source
Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. [PDF]
J Biol Chem, 2013 Kilari S +9 more
europepmc +2 more sources
Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report
BMC Cancer, 2018 Background Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. Apatinib, a novel tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR2), has ...
Lishu Yang +4 more
doaj +1 more source
Haematologica, 2009 Background The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate form ...
Margarita Pérez-Casal +5 more
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Isolation of a Novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library
Iranian Journal of Allergy, Asthma and Immunology, 2019 Vascular endothelial growth factor receptor 2 (VEGFR-2) is known as one of the important antigens playing a vital role in angiogenesis. In this study, phage display technology (PDT) was used to produce a single-chain variable fragment (scFv) antibody ...
Shirafkan Kordi +5 more
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2D interfacial diffusion model of inhibitory synaptic receptor dynamics [PDF]
, 2022 The lateral diffusion and trapping of protein receptors within the postsynaptic membrane of a neuron plays a key role in determining the strength of synaptic connections and their regulation during learning and memory. In this paper we construct and analyze a 2D interfacial diffusion model of inhibitory synaptic receptor dynamics.
arxiv +1 more source