Results 31 to 40 of about 32,949 (273)

Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis

BMC Nephrology, 2022
Background Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically determined. Herein, we focused on
Yue Qian, Li Ding, Liou Cao, Zanzhe Yu, Xinghua Shao, Ling Wang, Minfang Zhang, Qin Wang, Xiajing Che, Na Jiang, Hao Yan, Wei Fang, Yan Jin, Jiaying Huang, Aiping Gu, Zhaohui Ni   +15 more
doaj   +1 more source

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models [PDF]

Cancer Research, 2006
Abstract OSI-930 is a novel inhibitor of the receptor tyrosine kinases Kit and kinase insert domain receptor (KDR), which is currently being evaluated in clinical studies. OSI-930 selectively inhibits Kit and KDR with similar potency in intact cells and also inhibits these targets in vivo following oral dosing.
Andrew J. Garton, Andrew P. Crew, Maryland Franklin, Andrew Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric Brown, Mark Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew O’Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An‐Hu Li, Tao Zhang, Frank C. Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, Neil W. Gibson   +28 more
openalex   +4 more sources

Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report

BMC Cancer, 2018
Background Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. Apatinib, a novel tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR2), has ...
Lishu Yang, Lizhu Liu, Bo Han, Wei Han, Meng Zhao   +4 more
doaj   +1 more source

Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects

Haematologica, 2009
Background The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate form ...
Margarita Pérez-Casal, Colin Downey, Beatriz Cutillas-Moreno, Mirko Zuzel, Kenji Fukudome, Cheng Hock Toh   +5 more
doaj   +1 more source

Isolation of a Novel Anti-KDR3 Single-chain Variable Fragment Antibody from a Phage Display Library

Iranian Journal of Allergy, Asthma and Immunology, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) is known as one of the important antigens playing a vital role in angiogenesis. In this study, phage display technology (PDT) was used to produce a single-chain variable fragment (scFv) antibody ...
Shirafkan Kordi, Mohammad Rahmati-Yamchi, Mehdi Asghari Vostakolaei, Ali Etemadie, Abolfazl Barzegari, Jalal Abdolalizadeh   +5 more
doaj   +1 more source

Influence of KDR Genetic Variation on the Effectiveness and Safety of Bevacizumab in the First-Line Treatment for Patients with Advanced Colorectal Cancer

International Journal of General Medicine, 2022
Fei Wang,1 Gang Liu2 1Department of Oncology, The Seventh Medical Center of People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Department of General Surgery, The First Medical Center of People’s Liberation Army General ...
Wang F, Liu G
doaj  

Chronic deficiency of nitric oxide affects hypoxia inducible factor-1α (HIF-1α) stability and migration in human endothelial cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Endothelial dysfunction in widely diffuse disorders, such as atherosclerosis, hypertension, diabetes and senescence, is associated with nitric oxide (NO) deficiency. Here, the behavioural and molecular consequences deriving from NO deficiency
Maria Grazia Cattaneo, Elisa Cappellini, Roberta Benfante, Maurizio Ragni, Fausta Omodeo-Salè, Enzo Nisoli, Nica Borgese, Lucia M Vicentini   +7 more
doaj   +1 more source

Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene

Haematologica, 2016
Hodgkin lymphoma shows strong familial aggregation but no major susceptibility genes have been identified to date. The goal of this study was to identify high-penetrance variants using whole exome sequencing in 17 Hodgkin lymphoma prone families with ...
Melissa Rotunno, Mary L. McMaster, Joseph Boland, Sara Bass, Xijun Zhang, Laurie Burdett, Belynda Hicks, Sarangan Ravichandran, Brian T. Luke, Meredith Yeager, Laura Fontaine, Paula L. Hyland, Alisa M. Goldstein, NCI DCEG Cancer Sequencing Working Group, NCI DCEG Cancer Genomics Research Laboratory, Stephen J. Chanock, Neil E. Caporaso, Margaret A. Tucker, Lynn R. Goldin   +18 more
doaj   +1 more source

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

PLoS ONE, 2015
A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses and a sizeable fraction of ...
Adam A Friedman, Arnaud Amzallag, Iulian Pruteanu-Malinici, Subash Baniya, Zachary A Cooper, Adriano Piris, Leeza Hargreaves, Vivien Igras, Dennie T Frederick, Donald P Lawrence, Daniel A Haber, Keith T Flaherty, Jennifer A Wargo, Sridhar Ramaswamy, Cyril H Benes, David E Fisher   +15 more
doaj   +1 more source

Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2018
The complement system participates in the pathogenesis of many diseases. Complement activation produces several active protein complexes and peptides, including the terminal C5b-9 complexes.
Michal Lusthaus, Niv Mazkereth, Natalie Donin, Zvi Fishelson   +3 more
doaj   +1 more source