Results 41 to 50 of about 32,949 (273)

Angiogenesis system, as a part of endothelial dysfunction in patients with diabetes mellitus type 2: relationship with obesity

Терапевтический архив, 2020
Aim.To investigate parameters of angiogenesis system in patients with diabetes mellitus and their relationship with obesity. Materials and methods.104 patients with diabetes mellitus type 2 were included in the study. Patients were divided in 2 groups:
A. S. Severina, M. V. Shestakova
doaj   +1 more source

Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
This study was aimed to identify the expression pattern of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and to explore its potential correlation with the progression of NSCLC.Gene expression profile GSE39345 was ...
Ying Wang, Lu Huang, Shuqiang Wu, Yongshi Jia, Yunmei Yang, Limin Luo, Aihong Bi, Min Fang   +7 more
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Association of KDR rs1870377 genotype with clopidogrel resistance in patients with post percutaneous coronary intervention

Heliyon, 2021
Background: Clopidogrel is an antiplatelet therapy that is widely used in pre and post percutaneous (PCI) coronary intervention procedures to prevent platelet aggregation and stent restenosis.
Wajdy Al Awaida, Ali A. Ahmed, Asia Ali Hamza, Khalid I. Amber, Hamzeh J. Al-Ameer, Yazun Jarrar, Ghizal Fatima, Ahmed O. Maslat, Yulia Gushchina, Omar Al bawareed, Najah R. Hadi   +10 more
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Amino substituted nitrogen heterocycle ureas as kinase insert domain containing receptor (KDR) inhibitors: Performance of structure–activity relationship approaches

Journal of Food and Drug Analysis, 2015
A quantitative structure-activity relationship (QSAR) study was performed on a set of amino-substituted nitrogen heterocyclic urea derivatives. Two novel approaches were applied: (1) the simplified molecular input-line entry systems (SMILES) based optimal descriptors approach; and (2) the fragment-based simplex representation of molecular structure ...
Hayriye Yilmaz, Natalia Sizochenko, Bakhtiyor Rasulev, Andrey A. Toropov, Yahya Güzel, Виктор Евгеньевич Кузьмин, Danuta Leszczyńska, Jerzy Leszczyński   +7 more
openalex   +4 more sources

Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses

Frontiers in Pharmacology, 2022
Although the protective effects of naringenin (Nar) on vascular smooth muscle cells (VSMCs) have been confirmed, whether it has anti-proliferation and anti-migration effects in high-glucose-induced VSMCs has remained unclear.
Wenjun He, Wenjun He, Wenjun He, Yanming Wang, Yanming Wang, Yanming Wang, Rui Yang, Rui Yang, Rui Yang, Huihui Ma, Huihui Ma, Huihui Ma, Xuqing Qin, Xuqing Qin, Xuqing Qin, Meijuan Yan, Meijuan Yan, Meijuan Yan, Yi Rong, Yi Rong, Yi Rong, Yufang Xie, Yufang Xie, Yufang Xie, Li Li, Junqiang Si, Junqiang Si, Junqiang Si, Xinzhi Li, Xinzhi Li, Xinzhi Li, Ketao Ma, Ketao Ma, Ketao Ma   +33 more
doaj   +1 more source

Thiazolidinediones enhance vascular endothelial growth factor expression and induce cell growth inhibition in non-small-cell lung cancer cells

Journal of Experimental & Clinical Cancer Research, 2010
Background It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PPARγ); VEGF is a prognostic ...
Yoshizaki Yumiko, Kumei Shima, Tanno Sachie, Motomura Wataru, Yoshizaki Takayuki, Tanno Satoshi, Okumura Toshikatsu   +6 more
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Unusual duplication of the insulin-like receptor in the crustacean Daphnia pulex

BMC Evolutionary Biology, 2010
Background The insulin signaling pathway (ISP) has a key role in major physiological events like carbohydrate metabolism and growth regulation. The ISP has been well described in vertebrates and in a few invertebrate model organisms but remains largely ...
Dufresne France, Ditlecadet Delphine, Dubé Caroline, Boucher Philippe   +3 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Supplementary Figure Legends from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models [PDF]

, 2023
Andrew J. Garton, Andrew P. Crew, Maryland Franklin, Andrew Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric N. Brown, Mark Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew J. O’Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An‐Hu Li, Tao Zhang, Frank C. Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, Neil W. Gibson   +28 more
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Influence of KDR Genetic Variation on the Efficacy and Safety of Patients with Chemotherapy Refractory Metastatic CRC Who Received Apatinib Treatment

International Journal of General Medicine, 2021
Ming Bai,1,* Zhi-Guo Li,2,* Yi Ba1 1Department of Gastrointestinal Oncology, Affiliated Tumor Hospital of Tianjin Medical University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s ...
Bai M, Li ZG, Ba Y
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