Results 41 to 50 of about 187,132 (199)

Influence of KDR Genetic Variation on the Effectiveness and Safety of Bevacizumab in the First-Line Treatment for Patients with Advanced Colorectal Cancer

International Journal of General Medicine, 2022
Fei Wang,1 Gang Liu2 1Department of Oncology, The Seventh Medical Center of People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Department of General Surgery, The First Medical Center of People’s Liberation Army General ...
Wang F, Liu G
doaj  

Chronic deficiency of nitric oxide affects hypoxia inducible factor-1α (HIF-1α) stability and migration in human endothelial cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Endothelial dysfunction in widely diffuse disorders, such as atherosclerosis, hypertension, diabetes and senescence, is associated with nitric oxide (NO) deficiency. Here, the behavioural and molecular consequences deriving from NO deficiency
Maria Grazia Cattaneo, Elisa Cappellini, Roberta Benfante, Maurizio Ragni, Fausta Omodeo-Salè, Enzo Nisoli, Nica Borgese, Lucia M Vicentini   +7 more
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Follicle-stimulating hormone receptor: Advances and remaining challenges [PDF]

In: Arun K. Shukla (ed.), dir., G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A (p. 1-58). International Review of Cell and Molecular Biology, 338 (1\`ere ed.). USA : Elsevier. 171 p. (2018), 2018
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).
arxiv   +1 more source

Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene

Haematologica, 2016
Hodgkin lymphoma shows strong familial aggregation but no major susceptibility genes have been identified to date. The goal of this study was to identify high-penetrance variants using whole exome sequencing in 17 Hodgkin lymphoma prone families with ...
Melissa Rotunno, Mary L. McMaster, Joseph Boland, Sara Bass, Xijun Zhang, Laurie Burdett, Belynda Hicks, Sarangan Ravichandran, Brian T. Luke, Meredith Yeager, Laura Fontaine, Paula L. Hyland, Alisa M. Goldstein, NCI DCEG Cancer Sequencing Working Group, NCI DCEG Cancer Genomics Research Laboratory, Stephen J. Chanock, Neil E. Caporaso, Margaret A. Tucker, Lynn R. Goldin   +18 more
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Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1 [PDF]

arXiv, 2023
Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in
arxiv  

Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]

Journal of Chemical Information and Modeling, 2018, 2018
Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv   +1 more source

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

PLoS ONE, 2015
A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses and a sizeable fraction of ...
Adam A Friedman, Arnaud Amzallag, Iulian Pruteanu-Malinici, Subash Baniya, Zachary A Cooper, Adriano Piris, Leeza Hargreaves, Vivien Igras, Dennie T Frederick, Donald P Lawrence, Daniel A Haber, Keith T Flaherty, Jennifer A Wargo, Sridhar Ramaswamy, Cyril H Benes, David E Fisher   +15 more
doaj   +1 more source

Angiogenesis system, as a part of endothelial dysfunction in patients with diabetes mellitus type 2: relationship with obesity

Терапевтический архив, 2020
Aim.To investigate parameters of angiogenesis system in patients with diabetes mellitus and their relationship with obesity. Materials and methods.104 patients with diabetes mellitus type 2 were included in the study. Patients were divided in 2 groups:
A. S. Severina, M. V. Shestakova
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Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
This study was aimed to identify the expression pattern of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and to explore its potential correlation with the progression of NSCLC.Gene expression profile GSE39345 was ...
Ying Wang, Lu Huang, Shuqiang Wu, Yongshi Jia, Yunmei Yang, Limin Luo, Aihong Bi, Min Fang   +7 more
doaj   +1 more source

Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses

Frontiers in Pharmacology, 2022
Although the protective effects of naringenin (Nar) on vascular smooth muscle cells (VSMCs) have been confirmed, whether it has anti-proliferation and anti-migration effects in high-glucose-induced VSMCs has remained unclear.
Wenjun He, Wenjun He, Wenjun He, Yanming Wang, Yanming Wang, Yanming Wang, Rui Yang, Rui Yang, Rui Yang, Huihui Ma, Huihui Ma, Huihui Ma, Xuqing Qin, Xuqing Qin, Xuqing Qin, Meijuan Yan, Meijuan Yan, Meijuan Yan, Yi Rong, Yi Rong, Yi Rong, Yufang Xie, Yufang Xie, Yufang Xie, Li Li, Junqiang Si, Junqiang Si, Junqiang Si, Xinzhi Li, Xinzhi Li, Xinzhi Li, Ketao Ma, Ketao Ma, Ketao Ma   +33 more
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