Results 51 to 60 of about 32,949 (273)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Provoked anger is associated with an increased risk of cardiovascular disease events. The underlying mechanism linking provoked anger as well as other core negative emotions including anxiety and sadness to cardiovascular disease remain ...
Daichi Shimbo, Morgan T. Cohen, Matthew McGoldrick, Ipek Ensari, Keith M. Diaz, Jie Fu, Andrea T. Duran, Shuqing Zhao, Jerry M. Suls, Matthew M. Burg, William F. Chaplin   +10 more
doaj   +1 more source

Assessment of Control Tissue for Gene and Protein Expression Studies: A Comparison of Three Alternative Lung Sources

The Scientific World Journal, 2012
The use of an appropriate control group in human research is essential in investigating the level of a pathological disorder. This study aimed to compare three alternative sources of control lung tissue and to determine their suitability for gene and ...
Margaret R. Passmore, Maria Nataatmadja, John F. Fraser   +2 more
doaj   +1 more source

The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization. [PDF]

PLoS ONE, 2012
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease ...
Young Seok Park, Young Joo Jeon, Hyun Seok Kim, Kyu Young Chae, Seung-Hun Oh, In Bo Han, Hyun Sook Kim, Won-Chan Kim, Ok-Joon Kim, Tae Gon Kim, Joong-Uhn Choi, Dong-Seok Kim, Nam Keun Kim   +12 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

ROLE OF POLYMORPHISMS IN VEGF AND KDR GENES IN OSTEOSARCOMA SUSCEPTIBILITY: A SYSTEMATIC REVIEW [PDF]

Acta Ortopédica Brasileira
Osteosarcoma is the most common aggressive primary bone tumor in children and adolescents. Angiogenesis, induced by vascular endothelial growth factor (VEGF) and its receptor (kinase insert domain receptor - KDR) is involved in tumor development.
AMANDA DOS SANTOS CAVALCANTI, JÉSSICA VILARINHO CARDOSO, VERÔNICA ARAN PONTE, JADE PIRES NASCIMENTO, MARIANA CHANTRE-JUSTINO, ANA CRISTINA DE SÁ LOPES, WALTER MEOHAS, JAMILA ALESSANDRA PERINI   +7 more
doaj   +1 more source

Compositional change of gut microbiome and osteocalcin expressing endothelial progenitor cells in patients with coronary artery disease.

PLoS ONE, 2021
Osteogenic endothelial progenitor cells (EPCs) contribute to impaired endothelial repair and promote coronary artery disease (CAD) and vascular calcification. Immature EPCs expressing osteocalcin (OCN) has been linked to unstable CAD; however, phenotypic
Takumi Toya, Ilke Ozcan, Michel T Corban, Jaskanwal D Sara, Eric V Marietta, Ali Ahmad, Irina E Horwath, Darrell L Loeffler, Joseph A Murray, Lilach O Lerman, Amir Lerman   +10 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A rapid analysis method to discover antioxidant active components and mechanisms in soybean: untargeted metabolomics combined with network pharmacology and spectrum-effect relationship-component knockout-identification techniques

Food Science and Human Wellness
Soybean is widely used in diets, and numerous reports have highlighted its antioxidant properties. However, constructing a methodology for rapid identifying and predicting a series of antioxidant active ingredients in Soybean presents certain challenges.
Xuqiang Liu, Xinjing Meng, Dongqi Liu, Junshang Liu, Mengqi Lan, Wenyi Kang   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source