Results 51 to 60 of about 187,132 (199)
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]
The EMBO Journal 27, 9 (2008) 1321-1332, 2008 The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv +1 more source
Frontiers in Immunology, 2018 The complement system participates in the pathogenesis of many diseases. Complement activation produces several active protein complexes and peptides, including the terminal C5b-9 complexes.
Michal Lusthaus +3 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2010 Background It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PPARγ); VEGF is a prognostic ...
Yoshizaki Yumiko +6 more
doaj +1 more source
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization [PDF]
, 2018 Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial. Here we consider a lattice model yielding a phase diagram that includes several states proposed to be relevant for the cell membrane ...
arxiv +1 more source
International Journal of General Medicine, 2021 Ming Bai,1,* Zhi-Guo Li,2,* Yi Ba1 1Department of Gastrointestinal Oncology, Affiliated Tumor Hospital of Tianjin Medical University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s ...
Bai M, Li ZG, Ba Y
doaj
Unusual duplication of the insulin-like receptor in the crustacean
BMC Evolutionary Biology, 2010 Background The insulin signaling pathway (ISP) has a key role in major physiological events like carbohydrate metabolism and growth regulation. The ISP has been well described in vertebrates and in a few invertebrate model organisms but remains largely ...
Dufresne France +3 more
doaj +1 more source
PLoS ONE, 2021 Osteogenic endothelial progenitor cells (EPCs) contribute to impaired endothelial repair and promote coronary artery disease (CAD) and vascular calcification. Immature EPCs expressing osteocalcin (OCN) has been linked to unstable CAD; however, phenotypic
Takumi Toya +10 more
doaj +1 more source
MIK2 is a candidate gene of the S-locus for sporophytic self-incompatibility (SSI) in chicory (Cichorium intybus, Asteraceae) [PDF]
arXiv, 2023 The Cichorium genus offers a unique opportunity to study the sporophytic self incompatibility (SSI) system, being composed of species characterized by highly efficient SI (C. intybus) and complete self compatibility (C. endivia). The chicory genome was used to map 7 previously identified SSI locus-associated markers.
arxiv
Supplementary Tables 1-2 from OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models [PDF]
, 2023 Andrew J. Garton +28 more
openalex +2 more sources