Results 1 to 10 of about 1,477,881 (298)
Journal of Advanced Research, 2023 Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic ...
Moustafa A. Shehata +6 more
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Mechanistic target of rapamycin signaling in human nervous system development and disease
Frontiers in Molecular Neuroscience, 2022 Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates fundamental cellular processes including growth control, autophagy and metabolism. mTOR has key functions in nervous system development and mis-regulation
Marie Girodengo +3 more
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Nature Communications, 2023 Developmental and epileptic encephalopathies (DEEs) are a group of rare childhood disorders characterized by severe epilepsy and cognitive deficits. Numerous DEE genes have been discovered thanks to advances in genomic diagnosis, yet putative molecular ...
Marisol Sampedro-Castañeda +9 more
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Scientific Reports, 2023 Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic ...
María Jimena Rodriguez +12 more
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Nature Communications, 2023 Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández +10 more
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ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress
Frontiers in Cell and Developmental Biology, 2021 Autophagy is a highly conserved intracellular process that preserves cellular homeostasis by mediating the lysosomal degradation of virtually any component of the cytoplasm.
Andrés Gámez-García +12 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A new series of piperine-carboximidamide hybrids VIa-k was developed as a new cytotoxic agent targeting EGFR, BRAF, and CDK2. The antiproliferative effect against four cancer cells was investigated against erlotinib.
Lamya H. Al-Wahaibi +4 more
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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System
Frontiers in Systems Neuroscience, 2022 Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
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Molecular Systems Biology, 2021 Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced by massive cytokine production, cellular triggers of this process and strategies to target them remain poorly understood.
Marina Chan +5 more
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Identification of Potential Kinase Inhibitors within the PI3K/AKT Pathway of Leishmania Species
Biomolecules, 2021 Leishmaniasis is a public health disease that requires the development of more effective treatments and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been successfully studied as an effective anticancer strategy ...
Rodrigo Ochoa +7 more
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