Results 11 to 20 of about 147,757 (263)

Beyond PI3Ks: targeting phosphoinositide kinases in disease. [PDF]

, 2022
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death and are generated by the tightly regulated activity of phosphoinositide kinases. Although extensive efforts have focused on drugging class I phosphoinositide 3-
Emerling, Brooke M., Brooke M. Emerling, Gerald R. V. Hammond, Hammond, Gerald R V, Burke, John E., John E. Burke, Triscott, Joanna, Hammond, Gerald R. V., Burke, John E, Emerling, Brooke M, Joanna Triscott   +10 more
core   +1 more source

SnRK2 Protein Kinases-Key Regulators of Plant Response to Abiotic Stresses [PDF]

, 2011
The SnRK2 family members are plant-specific serine/threonine kinases involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development.
Wawer, Izabela, Kulik, Anna, Grażyna Dobrowolska, Anna Kulik, Bucholc, Maria, Izabela Wawer, Dobrowolska, Grażyna, Krzywińska, Ewa, Maria Bucholc, Ewa Krzywińska   +9 more
core   +2 more sources

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

Biomolecules, 2022
Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in ...
Said Moshawih, Ai Fern Lim, Chrismawan Ardianto, Khang Wen Goh, Nurolaini Kifli, Hui Poh Goh, Qais Jarrar, Long Chiau Ming   +7 more
doaj   +1 more source

fhlab/Kinases: Clarified code organization

, 2021
Added source data to the folder 'data' Reorganised analysis scripts in the folder 'results' to clarify the order of running Full Changelog: https://github.com/fhlab/Kinases/compare/v1.0.0...v1.1.
Chris Kitching, HollfelderLab, MayaPetek
core   +1 more source

Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]

, 2011
NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
core   +1 more source

YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis

Frontiers in Plant Science, 2023
IntroductionReceptor-like cytoplastic kinases (RLCKs) are known in many plants to be involved in various processes of plant growth and development and regulate plant immunity to pathogen infection.
Jinlan Fang, Jinlan Fang, Zhe Chai, Zhe Chai, Run Huang, Cuilin Huang, Zhenhua Ming, Baoshan Chen, Wei Yao, Wei Yao, Muqing Zhang, Muqing Zhang   +11 more
doaj   +1 more source

Functional characterization of human NDR kinases : novel regulatory mechanisms and a path towards direct substrates [PDF]

, 2012
Protein kinases are important regulators of signal transduction pathways in both unicellular and multicellular organisms. They play critical roles in biological processes such as cell growth, division, differentiation, adhesion, motility and cell death ...
Kohler, Reto
core   +1 more source

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases

Viruses, 2023
Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of activity. In fact,
Rima Hajjo, Dima A. Sabbah, Osama H. Abusara, Reham Kharmah, Sanaa Bardaweel   +4 more
doaj   +1 more source