Results 21 to 30 of about 1,477,881 (298)

2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation

Life, 2022
New quinazoline derivatives were designed based on the structural modification of the reported inhibitors to enhance their selectivity toward Aurora A. The synthesized compounds were tested over Aurora A, and a cytotoxicity assay was performed over NCI ...
Mohamed H. Elsherbeny, Usama M. Ammar, Magda H. Abdellattif, Mohammed A. S. Abourehab, Ahmed Abdeen, Samah F. Ibrahim, Doaa Abdelrahaman, Wessam Mady, Eun Joo Roh, Ahmed Elkamhawy   +9 more
doaj   +1 more source

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

eLife, 2021
Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the class IB PI3K catalytic subunit (p110γ) playing key roles in immune signalling.
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke   +8 more
doaj   +1 more source

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia [PDF]

Journal of Biological Chemistry, 2016
Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance.
Roth Flach, Rachel J., Danai, Laura V., DiStefano, Marina, Kelly, Mark, Menendez, Lorena Garcia, Jurczyk, Agata, Sharma, Rohit B., Jung, Dae Young, Kim, Jong Hun, Kim, Jason K, Bortell, Rita, Alonso, Laura C., Czech, Michael P.   +12 more
openaire   +3 more sources

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Journal of Biological Chemistry, 1987
Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-src and pp110gag-fes was inhibited in vitro by an isoflavone genistein.
Tetsu AkiyamaSO, Junko IshidaST, Suguru NakagawaS, H. Ogawara, Shun‐ichi Watanabe, Noriki Itoh, Masabumi ShibuyaSS, Y. Fukami   +7 more
semanticscholar   +1 more source

Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure

Frontiers in Physiology, 2021
High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating several mechanisms at the physiological, cellular, and molecular levels and triggering the development of several pathologies.
Patricia Siques, Eduardo Pena, Julio Brito, Samia El Alam   +3 more
doaj   +1 more source

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

Frontiers in Cellular and Infection Microbiology, 2013
Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective.
Kun eShi, Shane J. Caldwell, Desiree H. Fong, Albert M. Berghuis, Albert M. Berghuis   +4 more
doaj   +1 more source

Kinase Signaling in Dendritic Development and Disease

Frontiers in Cellular Neuroscience, 2021
Dendrites undergo extensive growth and remodeling during their lifetime. Specification of neurites into dendrites is followed by their arborization, maturation, and functional integration into synaptic networks.
Kimya Nourbakhsh, Smita Yadav
doaj   +1 more source

Phylogenetic, structure and expression analysis of ABC1Ps gene family in rice

Biologia Plantarum, 2012
The ABC1 protein family (ABC1P), a new family of putative kinases, widely existed in procaryote and eucaryote. A comprehensive genome-wide analysis was carried out in this study to find all ABC1Ps in rice (Oryza sativa subsp. japonica).
S. G. Yang, T. Li, M. Liu, S. J. Gao, S. Y. Yang, L. Li, C. W. Yang   +6 more
doaj   +1 more source

Nuclear Phosphoinositides as Key Determinants of Nuclear Functions

Biomolecules, 2023
Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell.
Magdalena C. Vidalle, Bhavwanti Sheth, Antonietta Fazio, Maria Vittoria Marvi, Stefano Leto, Foteini-Dionysia Koufi, Irene Neri, Irene Casalin, Giulia Ramazzotti, Matilde Y. Follo, Stefano Ratti, Lucia Manzoli, Sonakshi Gehlot, Nullin Divecha, Roberta Fiume   +14 more
doaj   +1 more source

The Signaling Mechanism of Remote Postconditioning of the Heart: Prospects of the Use of Remote Postconditioning for the Treatment of Acute Myocardial Infarction

Cells, 2023
Acute myocardial infarction (AMI) remains the leading cause of mortality in the world, highlighting an urgent need for the development of novel, more effective approaches for the treatment of AMI.
Vyacheslav V. Ryabov, Evgenii V. Vyshlov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Natalia V. Naryzhnaya, Alla A. Boshchenko, Aleksandra E. Gombozhapova, Julia O. Samoylova   +7 more
doaj   +1 more source