Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Intensive care of the very old - questioning the relationship between illness severity and the moral imperative to deliver life-saving care. [PDF]
Philos Ethics Humanit MedSchwarz GL.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Organising housing and service provision for persons with co-occurring substance use and mental health problems: a scoping review in the ROP Municipal. [PDF]
BMC PsychiatrySorsa M +4 more
europepmc +1 more source
Public attitudes towards the mentally ill: A cross‐cultural study between Bali and Tokyo
Psychiatry and Clinical Neurosciences, 2000 T. Kurihara +4 more
semanticscholar +1 more source
Sex Offenses: The Marginal Status of the Adolescent [PDF]
, 1960 Reiss, Albert J.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Support Needs and Available Resources for School-Aged Siblings of Children With Disabilities: A Mixed Methods Study. [PDF]
J Appl Res Intellect DisabilVeerman LKM +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Utility or futility? Toward an operational definition of addiction 'recovery'. [PDF]
Addict Res TheoryKelly JF, Stauffer W.
europepmc +1 more source