FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Intensive care of the very old - questioning the relationship between illness severity and the moral imperative to deliver life-saving care. [PDF]
Philos Ethics Humanit MedSchwarz GL.
europepmc +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Potentially inappropriate medication use in older adult patients living with cancer using the Beers, STOPP, GO-PIM and Chinese criteria: A retrospective cross-sectional study. [PDF]
Medicine (Baltimore)Liu Y, Su Q, Wu D, Li X, Wang X.
europepmc +1 more source
How to enhance the external validity of survey experiments? A discussion on the basis of a research design on political gender stereotypes in Flanders [PDF]
, 2016 Devroe, Robin
core
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Bridging Integrative Medicine and AI: A Zhuangzian Perspective. [PDF]
NanoethicsCordeiro-Rodrigues L +2 more
europepmc +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Mental Illness and Serious Crime: Analysis of the Judicial Response and the Limitations of the Spanish Penitentiary System. [PDF]
Rev Esp Sanid PenitSalmón-Maroto R.
europepmc +1 more source
Adding a Third Dimension: The Danadian Approach to Constitutional Equality Guarantees [PDF]
, 1992 Smith, C. Lynn
core +1 more source