Results 141 to 150 of about 590,200 (259)

Non-Pharmacological Breathlessness Action Plans for People with COPD and Their Support People: A Scoping Review and Survey of Current Practice. [PDF]

Int J Chron Obstruct Pulmon Dis
Luckett T, Roberts MM, Chaudhry MT, Hancock J, Ruttle L, Siemionow M, Smith K, River J, Johnson M, Smith TA, Johnston KN, Hutchinson A, Swan F, Pearson M, Crooks MG, Kochovska S, Keijzers G, Keedwell A, Agar MR, Currow DC, Rhee J, Erfani E, Williams MT.   +22 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of Psychological Interventions on Itch, Scratching, and Excoriations: A Systematic Review and Meta-analysis. [PDF]

Acta Derm Venereol
Schut C, Munz J, Maas Genannt Bermpohl F, Van Laarhoven AIM, Schmidt J, Evers AWM, Kupfer J.   +6 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Social Pressure to Reduce Alcohol Drinking and Mortality 20 years Later in a General Population Sample: A Cohort Study. [PDF]

Subst Use
John U, Rumpf HJ, Hanke M, Meyer C.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The relationship between capacity and credibility: implications for epistemic injustice. [PDF]

Med Law Rev
Reed-Berendt R, Ganguli-Mitra A.
europepmc   +1 more source

The Principles and the Presumption of Equality [PDF]

, 2015
Gosepath, Stefan
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Patients' Experiences in Inviting Healthcare Persons Into Caring Relationships: A Thematic Analysis. [PDF]

Scand J Caring Sci
Portaankorva ML, Kasén A, Fagerström L, Vaartio-Rajalin H.   +3 more
europepmc   +1 more source