Results 61 to 70 of about 402,340 (304)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Análise quiral por espectrometria de massas através da utilização do método cinético

Química Nova, 2006
Novel and quantitative mass spectrometry methods for rapid and accurate enantiomeric excess determination are presented. These methodologies use electrospray ionization (ESI) and mass spectrometry (MS) to detect and analyze, via collision-induced ...
Augusti Daniella Vasconcellos, Augusti Rodinei   +1 more
doaj  

Kinetic Bacterial Endotoxin Testing Methods: Specifics of Analytical Conditions Exemplified by Medicinal Products from Different Classes

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Kinetic bacterial endotoxin (BE) testing methods based on amoebocyte lysate from the haemolymph of the horseshoe crab can quantify BEs in parenteral medicinal products across a broad range of concentrations. To develop a specific analytical
О. V. Shapovalova, N. P. Neugodova, G. A. Sapozhnikova   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Efficient simulation of stochastic chemical kinetics with the Stochastic Bulirsch-Stoer extrapolation method [PDF]

, 2014
BackgroundBiochemical systems with relatively low numbers of components must be simulated stochastically in order to capture their inherent noise. Although there has recently been considerable work on discrete stochastic solvers, there is still a need ...
Barrio Solórzano, Manuel, Zygalakis, Konstantinos C., Kevin Burrage, Manuel Barrio, Zygalakis, Konstantinos C, Székely, Tamás, Burrage, Kevin, Barrio, Manuel, Szekely Jr, Tamas, Tamás Székely, Konstantinos C Zygalakis, Zygalakis, Konstantinos   +11 more
core   +1 more source

Kinetic determination of As(III) in solution [PDF]

Journal of the Serbian Chemical Society, 2003
A new reaction is suggested and a new kinetic method is elaborated for the As(III) traces determination in solution, on the basis of their catalyzing effect on komplexon III (EDTA) oxidation by KMnO4 in a strong acid solution (H2SO4).
TODOR G. PECEV, RANGEL P IGOV, SOFIJA M. RANCIC   +2 more
doaj  

PolyPIC: The Polymorphic-Particle-in-Cell Method for Fluid-Kinetic Coupling

Frontiers in Physics, 2018
Particle-in-Cell (PIC) methods are widely used computational tools for fluid and kinetic plasma modeling. While both the fluid and kinetic PIC approaches have been successfully used to target either kinetic or fluid simulations, little was done to ...
Stefano Markidis, Vyacheslav Olshevsky, Chaitanya Prasad Sishtla, Steven W. D. Chien, Erwin Laure, Giovanni Lapenta   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A thermo-mechanically consistent Burnett regime continuum flow equation without Chapman-Enskog expansion [PDF]

, 2013
Chapman-Enskog expansion is the orthodox approach to derive continuum flow models from Boltzmann’s kinetic equation for dilute gases. Beyond the Navier-Stokes-Fourier order, these models known as Burnett hydrodynamic-regime equations violate a number of ...
Dadzie, Kokou, Dadzie, Kokou; id_orcid
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source