Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]
, 2016 Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D. +7 more
core +3 more sources
Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. [PDF]
, 2020 BackgroundMetastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes.
Cadaneanu, Radu M +14 more
core
Modeling, Calibration, and Evaluation of a Tendon-Actuated Planar Parallel Continuum Robot [PDF]
, 2020 In this work, a novel planar parallel continuum robot (PCR) is introduced, consisting of three kinematic chains that are coupled at a triangular end-effector platform and include tendon-actuated continuum segments.
Burgner-Kahrs, Jessica +5 more
core +2 more sources
Contact Force Estimation of Continuum Robots without Embedded Sensors: A Review
Advanced Intelligent Systems, EarlyView.This review surveys methods for estimating contact forces in continuum robots without embedded sensors. It explains why contact force matters, classifies force patterns, and groups existing methods into three approaches based on actuation, deformation, and environment information.
An Hu, Yu Sun
wiley +1 more source
Voluntary Pilot Action Through Biodynamics for Helicopter Flight Dynamics Simulation [PDF]
, 2015 This work presents the integration of detailed models of a pilot controlling a helicopter along the heave axis through the collective control inceptor. The action on the control inceptor is produced through a biomechanical model of the pilot’s limbs, by ...
A., Bernardini +3 more
core +1 more source
Advanced Science, Volume 12, Issue 30, August 14, 2025.KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma +9 more
wiley +1 more source
Advancing Stability in Robot Manipulators: A Review of Recent Progress and Parameters
Engineering Reports, Volume 7, Issue 7, July 2025.We present an overview of the current state‐of‐the‐art in robotics while emphasizing stability and control aspects with pragmatic consideration over robotic manipulators. It is centered on robustness, efficiency, and security for applications such as industrial automation or surgical robotics.
Shabnom Mustary +4 more
wiley +1 more source
Robot's hand and expansions in non-integer bases
, 2014 We study a robot hand model in the framework of the theory of expansions in non-integer bases. We investigate the reachable workspace and we study some configurations enjoying form closure properties.Comment: 22 pages, 10 ...
Lai, Anna Chiara, Loreti, Paola
core +3 more sources
A preliminary synthesis of a light and compact wearable cable-driven parallel robot for wrist joint rehabilitation [PDF]
, 2022 Robot-assisted rehabilitation has proven to be effective in clinical practice, not only because of its ability to perform repetitive and intensive rehabilitation therapy but also because its rehabilitation outcome is not limited by the lack of ...
Botta, Andrea +6 more
core +1 more source
Learning Controllers for Continuum Soft Manipulators: Impact of Modeling and Looming Challenges
Advanced Intelligent Systems, Volume 7, Issue 2, February 2025.Learning‐based controllers advance the control of continuum soft manipulators. In this article, by evaluating different forward models and their influence on control strategies, key challenges are highlighted and the way is paved for future research in integrating machine learning with soft robotics.
Egidio Falotico +10 more
wiley +1 more source