Results 51 to 60 of about 4,067,399 (297)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Kingdom of Bhutan

Political Observer | Revista Portuguesa de Ciência Política (Portuguese Journal of Political Science), 2019
Most democratic transitions have demonstrated how it is possible to move from an authoritarian starting point towards an ongoing state of compromise. The Kingdom of Bhutan, a small state bordering India and China and located deep within the Himalayan Mountains, stands as an illustrative case of that paradigm. Not only has that country recently welcomed
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Praying for the Coming of the Kingdom, Crystallizing Biblical Themes in Second Temple Prayers: The Shema, the Qaddish, and the Lord’s Prayer

Religions
Some studies have pointed to the Jewish background of the prayer that, according to the gospels of Matthew and Luke, Jesus taught his disciples. However, the formulations of LP’s words do not necessarily presuppose the conclusion of the formation of ...
Pino Di Luccio
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Journey to the Kingdom: The Three-Fold Compositional Arc of Book II of the Psalter

Perichoresis: The Theological Journal of Emanuel University
Employing the methodology of Editorial Criticism, this article seeks to demonstrate that Book II of the Psalter (i.e., Psalms 42-72) consists of three parallel, compositional arcs that take the form of a journey. Based on key-word links, as well as clear
Gilcher Jerod A.
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

الزخارف الحيوانية علي الفخار في الدولة الحديثة [PDF]

مجلة کلية الآداب. جامعة أسوان
تعود أهمية الزخارف المتنوعة علي الفخار في معرفة تفاصيل حياة المجتمعات ومظهراً للتقدم ومدي الذوق الفني أنذاك وتطور الفن خلال تلك القترة المصاحبة لظهوره, ونستنبط من موضوعات الزخرفة علي الفخار العادات الإجتماعية , والحياة الدينية , والمعبودات وممارسة الطقوس
عزت رجب عبد الله ابوطالب
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Nação

Ler História, 2008
The concept of nation has undergone a profound change between 1750 and 1850, only understandable in the context of historical changes that occurred following the French invasion.
Sérgio Campos Matos
doaj   +1 more source