Results 1 to 10 of about 5,840 (134)

Inhibition of lipolysis in visceral adipose tissue from obese mice and humans prevents impairment of endothelial Kir2.1 channels [PDF]

Channels
Accumulation of abdominal visceral adipose tissue (VAT) is a major risk factor for cardiovascular disease. Obesity-induced endothelial dysfunction is a precursor to severe disease, and we and others have shown that arteries embedded in VAT, but not ...
Emma C. Hudgins, Erica J. Johnson, Sabita Rokka, Bhaswati Kashyap, Arielle Mahugu, Thanh Nguyen, Anthony R. Tascone, Elizabeth McCarthy, Caitlin Halbert, Ibra S. Fancher   +9 more
doaj   +3 more sources

Activation of Kir2.1 improves myocardial fibrosis by inhibiting Ca ²⁺ overload and the TGF-β1/Smad signaling pathway

Acta Biochimica et Biophysica Sinica, 2023
The inwardly rectifying potassium channel Kir2.1 is closely associated with many cardiovascular diseases. However, the effect and mechanism of Kir2.1 in diabetic cardiomyopathy remain unclear.
Rong Yi, Zhou Xin, Guo Zhenli, Zhang Yingying, Qin Wenjuan, Li Li, Si Junqiang, Yang Rui, Li Xinzhi, Ma Ketao   +9 more
doaj   +2 more sources

Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking

Frontiers in Physiology, 2022
Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias.
Encan Li, Vera Loen, Willem B. van Ham, Willy Kool, Marcel A. G. van der Heyden, Hiroki Takanari   +5 more
doaj   +2 more sources

Activation of Smooth Muscle K_ir2.1 Channels and Na⁺/K⁺-ATPase Mediates Dilation of Porcine Coronary Arterioles at Physiological Levels of Potassium. [PDF]

Int J Mol Sci
Metabolic stress on the heart can cause dilation of coronary arterioles for blood flow recruitment. Although potassium ions (K+) released from the myocardium are a major mediator for this response, the underlying signaling pathways for vasodilation are ...
Hein TW, Razavi HM, Xu X, Somvanshi S, Muthuchamy M, Kuo L.   +5 more
europepmc   +2 more sources

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

Frontiers in Cell and Developmental Biology, 2022
Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager, Ceara K. McAtee, Mitchell A. Lesko, Allyson F. O’Donnell   +3 more
doaj   +2 more sources

Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: Inhibition potentiated by low Ba2+

Frontiers in Pharmacology, 2023
Sildenafil (Viagra), the first approved and widely used oral drug for the treatment of erectile dysfunction, was occasionally associated with life-threatening ventricular arrhythmias in patients.
Akimasa Iijima, Olga Švecová, Jan Hošek, Roman Kula, Markéta Bébarová   +4 more
doaj   +2 more sources

High-yield production and characterization of functional Kir2.1 ion channel using E. coli cell-free protein synthesis system [PDF]

Synthetic and Systems Biotechnology
A family of inwardly-rectifying potassium (Kir) channels plays a key role in the regulation of cellular potassium (K+) balance, affecting muscle, nerve and immune function.
Tianqi Zhou, Zitong Zhao, Huizi Zhang, Yunyang Song, Yifeng Yin, Fanghui Wu, Yanli Liu, Dan Xu   +7 more
doaj   +2 more sources

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Nature Communications, 2022
Potassium channels and membrane potential may influence macrophage function during inflammation. Here the authors show that the Kir2.1 potassium channel affects macrophage metabolism by altering cell surface retention of nutrient transporters and ...
Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, Di Wang   +20 more
doaj   +2 more sources

Kir2.1 Channel Contributes to Hypokalemia-Induced Abnormal Pacemaker Activities of Cardiomyocytes With Inward Rectification

Frontiers in Bioscience-Landmark
Background: Hypokalemia induces abnormal spontaneous pacemaker activities of cardiomyocytes, which is strongly associated with fatal cardiac arrhythmias caused by hypokalemia. However, the mechanism remains unclear.
Jinhua Lv, Yangxin Jiang, Jin Zeng, Dongchuan Zuo   +3 more
doaj   +2 more sources

Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

Molecular Medicine
Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions.
Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan, Haohao Zhang   +11 more
doaj   +2 more sources