Results 101 to 110 of about 5,909 (195)

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

A Novel KCNJ2 Mutation Identified in an Autistic Proband Affects the Single Channel Properties of Kir2.1

Frontiers in Cellular Neuroscience, 2018
Inwardly rectifying potassium channels (Kir) have been historically associated to several cardiovascular disorders. In particular, loss-of-function mutations in the Kir2.1 channel have been reported in cases affected by Andersen-Tawil syndrome while gain-
Anna Binda, Ilaria Rivolta, Chiara Villa, Elisa Chisci, Massimiliano Beghi, Cesare M. Cornaggia, Roberto Giovannoni, Romina Combi   +7 more
doaj   +1 more source

The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat. [PDF]

PLoS ONE, 2017
Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (IK1) in cardiomyocytes.
Xu-Wen Zhai, Li Zhang, Yun-Fei Guo, Ying Yang, Dong-Ming Wang, Yan Zhang, Pan Li, Yi-Fan Niu, Qi-Long Feng, Bo-Wei Wu, Ji-Min Cao, Qing-Hua Liu   +11 more
doaj   +1 more source

The Drosophila SIFamide Receptor Regulates Sleep and Feeding in a Time‐Of‐Day Specific Manner

Genes, Brain and Behavior, Volume 24, Issue 6, December 2025.
We found that mutations in the Drosophila SIFa receptor gene cause increases in locomotor activity and feeding behavior at specific times of day. This suggests that SIFa signaling exerts behavioral control to contribute to optimal energy balance. ABSTRACT To optimize health, organisms must coordinate energy intake and expenditure and apportion related ...
Anayatzi Velazquez, Madelyn R. Cusick, Siddarth De, Andi A. Beaudouin, Ariel Stepankovskaya, Justina A. Tidaback, Oleksandra Tsibere, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

Aloe-Emodin Relieves High-Fat Diet Induced QT Prolongation via MiR-1 Inhibition and IK1 Up-Regulation in Rats

Cellular Physiology and Biochemistry, 2017
Background/Aims: High-fat diet (HFD) causes cardiac electrical remodeling and increases the risk of ventricular arrhythmias. Aloe-emodin (AE) is an anthraquinone component isolated from rhubarb and has a similar chemical structure with emodin.
Yan Bai, Zhenli Su, Hanqi Sun, Wei Zhao, Xue Chen, Pengzhou Hang, Wenliang Zhu, Zhimin Du   +7 more
doaj   +1 more source

Epidermal growth factor receptor down-regulation triggers human myoblast differentiation. [PDF]

PLoS ONE, 2013
Initiation of human myoblast differentiation requires a negative shift (hyperpolarization) of the resting potential of myoblasts that depends on the activation of Kir2.1 potassium channels.
Marina C Leroy, Julie Perroud, Basile Darbellay, Laurent Bernheim, Stephane Konig   +4 more
doaj   +1 more source

Caveolin‐3 regulates subcellular targeting of Kir2.1 channels

The FASEB Journal, 2012
Inwardly rectifying potassium channels, Kir2 in particular, are crucial in shaping the action potential and stabilizing the resting potential. However, little is known about the subcellular localization of the Kir2.1 channel, an important component of the background current, IK1, in cardiac myocytes.
Zhaogang N/A Yang, Keli Hu
openaire   +1 more source

The Potassium Channel Kir2.1 Activity is Required for Osteoblastogenesis [PDF]

Biophysical Journal, 2012
Andersen's syndrome (AS) is a rare and dominant pathology linked to the inward rectifying potassium channel Kir 2.1. Patients exhibit a triad of symptoms: periodic paralysis, cardiac dysrhythmia and bone malformations. We have made progress in understanding the contribution of the Kir2.1 channel in skeletal and cardiac muscle dysfunctions but we are ...
Zaddam, Sonia, Sacconi, Sabrina, Desnuelle, Claude, Amri, Ez-zoubir, Saïd, Bendahhou   +4 more
openaire   +1 more source

When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

Annals of Noninvasive Electrocardiology, Volume 30, Issue 6, November 2025.
Recurrent syncope in a young woman was diagnosed as Andersen‐Tawil syndrome (ATS), characterized by prominent U waves and prolonged QTU intervals. Genetic testing confirmed a KCNJ2 mutation. Tailored treatment, including medication adjustments, led to symptom improvement, emphasizing the importance of accurate diagnosis and management in ATS.
Shasha Yu, Hang Lv
wiley   +1 more source

Cryo–electron microscopy unveils the gating mechanism of the human Kir2.1 channel

BIO Web of Conferences
Background Inward-rectifier potassium (Kir) channels are a group of integral membrane proteins that selectively control the permeation of K+ ions across cell membranes.
Catherine Vénien-Bryan, Carlos A. H. Fernandes, Dania Zuniga, Andreas Zoumpoulakis, Rafael F. Veloso, Renaud Wagner   +5 more
semanticscholar   +1 more source