Results 111 to 120 of about 5,909 (195)
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, Volume 5, Issue 9, September 2025.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Tumor Electrophysiology in Precision Tumor Therapy
iMetaMed, Volume 1, Issue 1, September 2025.This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, and how targeted intervention—including channel‐specific drugs, electric field therapies, and nanodrug delivery systems—can disrupt these processes ...
Kailai Li +8 more
wiley +1 more source
Voltage-dependent inhibition of outward Kir2.1 currents by extracellular spermine
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Outward currents through inward rectifier Kir2.1 channels play crucial roles in controlling the electrical properties of excitable cells. Extracellular monovalent and divalent cations have been shown to reduce outward K(+) conductance. In the present study, we examined whether spermine, with four positive charges, also inhibits outward Kir2.1 currents.
Chang, Hsueh-Kai, Shieh, Ru-Chi
openaire +2 more sources
Speed Endurance Training to Improve Performance
Scandinavian Journal of Medicine &Science in Sports, Volume 35, Issue 7, July 2025.ABSTRACT In many sports, the physical dimension plays a crucial role in determining athletic performance. This review provides insights into the effectiveness of speed endurance training (SET), that is, exercise training performed at intensities higher than that eliciting maximum oxygen uptake (V̇O2‐max), on performance across different sports and ...
Jens Bangsbo +2 more
wiley +1 more source
Engineering prokaryotic channels for control of mammalian tissue excitability
Nature Communications, 2016 Restoring lost excitability of injured tissue is a paramount of regenerative medicine. By using a combined expression of bacterial voltage-gated Na+ channel, Kir2.1, and connexin-43 in non-excitable human fibroblasts, here the authors generate excitable ...
Hung X. Nguyen +2 more
doaj +1 more source
Endozytose des Kaliumkanals Kir2.1
, 2015 We have studied some of the mechanisms responsible for controlling the density of Kir2.1 channels at the cell surface. In particular, we have explored the mechanisms underlying the of Kir2.1 channel into the endocytic pathway. We found that 1.
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Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1.
Cell Metabolism, 2022 Sheng Chen +24 more
semanticscholar +1 more source
Conformational changes in Kir2.1 channels during NH4+-induced inactivation.
The Journal of biological chemistry, 2003 We have shown previously that NH(4)(+) binding to the external pore of a Kir2.1 channel induces channel inactivation possibly through conformational changes. In this study, we performed further biophysical analyses of the NH(4)(+)-induced inactivation modeled by a refined kinetic scheme.
Hsueh-Kai, Chang, Ru-Chi, Shieh
openaire +1 more source
Indian Pacing and Electrophysiology Journal, 2006 Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Andrew H. Smith +2 more
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