Results 161 to 170 of about 5,909 (195)

The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila. [PDF]

PLoS Biol
Jones JD, Holder BL, Montgomery AC, McAdams CV, He E, Burns AE, Eiken KR, Vogt A, Velarde AI, Elder AJ, McEllin JA, Dissel S.   +11 more
europepmc   +1 more source

Sinoatrial Node Dynamics: Clinical Relevance and microRNA-Based Modulation of Pacemaker Activity. [PDF]

Cureus
Nur H.
europepmc   +1 more source

Ebbs and tides of endothelial K⁺ currents that regulate blood flow.

Am J Physiol Heart Circ Physiol
Martin PE, Pires PW.
europepmc   +1 more source

Projection neurons are necessary for the maintenance of the mouse olfactory circuit. [PDF]

Elife
Sánchez-Guardado L, Razavi P, Wang B, Callejas-Marín A, Lois C.   +4 more
europepmc   +1 more source

Purkinje cell intrinsic activity shapes cerebellar development and function

Osório C, White JJ, Solé PT, Mandemaker N, Olivero F, Kirwan F, de Winter F, Regolo E, Fiocchi FR, Serra I, Tjon S, Ozgur Z, van den Hout MC, van Ijcken WFJ, López-Bendito G, Badura A, Lim L, van Woerden G, Schonewille M.   +18 more
europepmc   +1 more source

Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome

Circulation Research
BACKGROUND: Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding the strong inwardly rectifying K+ channel Kir2.1.
F. M. Cruz, Á. Macías, A. Moreno-Manuel, L. Gutierrez, M. L. Vera-Pedrosa, I. Martínez-Carrascoso, Patricia Sánchez Pérez, Juan Manuel Ruiz Robles, F. Bermúdez-Jiménez, Aitor Díaz-Agustín, Fernando Martínez de Benito, S. Arias-Santiago, Aitana Braza-Boils, Mercedes Martín-Martínez, M. Gutiérrez-Rodríguez, J. Bernal, Esther Zorio, J. Jiménez-Jáimez, José Jalife   +18 more
semanticscholar   +5 more sources

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Kir2.1 channel: Macrophage plasticity in tumor microenvironment

Cell Metabolism, 2022
Diverse ion channels have dysregulated functional expression in the tumor microenvironment (TME). In this issue of Cell Metabolism, Chen et al. reveal that high intratumoral K+ ions restrict the plasticity of tumor-associated macrophages (TAMs). Inhibition of the Kir2.1 potassium channel induced metabolic reprogramming and repolarization of pro-tumor ...
Umar, Al-Sheikh, Lijun, Kang
openaire   +2 more sources

Kir2.1 Potassium channels and corneal epithelia

Current Eye Research, 2000
To determine the existence of inward rectifier (Kir2.1) sequences in mRNA from corneal epithelium and endothelium.cDNA library construction, cloning, PCR, patch clamp. RESULTS. Both the corneal epithelium and endothelium contain mRNA for Kir2.1 inwardly rectifying potassium channels.
J L, Rae, A R, Shepard
openaire   +2 more sources

Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-D-aspartate receptors in the regulation of cerebral blood flow.

International Journal of Biochemistry and Cell Biology, 2021
Neurovascular coupling (NVC) represents the mechanisms whereby an increase in neuronal activity (NA) may lead to local vasodilation and increase in regional cerebral blood flow (CBF).
Sharon Negri, Pawan Faris, T. Soda, F. Moccia   +3 more
semanticscholar   +1 more source

Stretch-induced alterations of human Kir2.1 channel currents

Biochemical and Biophysical Research Communications, 2006
The inward rectifier potassium channel, Kir2.1, contributes to the I(K1) current in cardiac myocytes and is closely associated with atrial fibrillation. Strong evidences have shown that atrial dilatation or stretch may result in atrial fibrillation. However, the role of Kir2.1 channels in the stretch-mediated atrial fibrillation is not clear.
Yusong, He, Junjie, Xiao, Yiqing, Yang, Qinshu, Zhou, Zhimin, Zhang, Qin, Pan, Yi, Liu, Yihan, Chen   +7 more
openaire   +2 more sources