Results 171 to 180 of about 5,909 (195)

Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824.

ACS Medicinal Chemistry Letters
ML133 is a selective inhibitor of the inward-rectifier potassium channel Kir2.1 and has found extensive use as a tool with which to probe Kir biology.
Renn A Duncan, Daniel H Haymer, Roman M. Lazarenko, Liangping Li, Yvette Blackwell, Emily L. Days, Srinivasan Krishnan, Analisa Thompson Gray, Olivier Boutaud, D. Engers, C. Lindsley, J. Denton, Aaron M. Bender   +12 more
semanticscholar   +1 more source

Kir2.1 channels drive macrophage migration through enhancing store-operated Ca2+ entry.

American Journal of Physiology - Cell Physiology
Kir2.1 is an inwardly rectifying K+ channel that is essential for the generation and regulation of the resting membrane potential in many types of cells such as cardiac myocytes.
Yoshiaki Suzuki, Taiju Katayama, Yu Fujita, Tsukasa Koide, Y. Sawai, Kazuki Maeda, Rubii Kondo, Wayne R. Giles, Yuji Imaizumi, H. Yamamura   +9 more
semanticscholar   +1 more source

Cholesterol Insensitive Kir2.1 is Protective Against Obesity as a Result of Improved Endothelial Function in Resistance Arteries

Physiology
Background: Inwardly Rectifying Potassium Channel 2.1 (Kir2.1) plays a key role in the maintenance of membrane potential in a variety of cell types and is critical for flow-induced vasodilation (FIV) in resistance arteries of mice and humans.
Katie M. Beverley, Elizabeth Le Master, S. J. Ahn, Sara Granados, Pingwen Xu, Irena A. Levitan   +5 more
semanticscholar   +1 more source

α1‐Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation

Experimental Physiology, 2022
What is the central question of this study? What is the mechanism of cardiac inflammation induced by α1‐adrenoceptor stimulation by NLRP3 inflammasome activation? What is the main finding and its importance?
Ling Chen, Wenbo Wang, Xiangyang Peng, Luqian Liu, Aimei Zhang, Xinzhi Li, Ketao Ma, Li Wang   +7 more
semanticscholar   +1 more source

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1.

The Journal of General Physiology
Precise control of Kir2.1 channel gating is essential for maintaining membrane potential and enabling repolarization in excitable cells. Disruption of Kir2.1 function can cause Andersen-Tawil syndrome type 1 (ATS1), a multisystem channelopathy that ...
Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D Gada, Takeharu Kawano, Meng Cui, Leigh D Plant   +9 more
semanticscholar   +1 more source

Potassium ion channel Kir2.1 negatively regulates protective responses to Mycobacterium bovis BCG.

Journal of Leukocyte Biology
Tuberculosis caused by the pathogen Mycobacterium tuberculosis leads to increased mortality and morbidity worldwide. The prevalence of highly drug resistant strains has reinforced the need for greater understanding of host-pathogen interactions at the ...
Vishal Sinha, Akshita Singh, Aarti Singh, S. S. K. Saraswati, A. Rana, Kanika Kalra, Krishnamurthy Natarajan   +6 more
semanticscholar   +1 more source

Neurovascular Uncoupling in TgF344‐AD Rats is Associated with Reduced Cerebral Capillary Endothelial Kir2.1 Expression

Alzheimer's & Dementia, 2022
Alzheimer’s disease (AD) is an emerging global health care crisis. Although reduced cerebral blood flow (CBF) is an early and persistent symptom in developing cognitive deficits, the underlying molecular and cellular mechanisms remain unclear.
Xing Fang, Jane J. Border, Reece F Crumpler, Luke B Strong, Richard J. Roman, Fan Fan   +5 more
semanticscholar   +1 more source

Surface translocation of Kir2.1 channel induces IL-1β secretion in microglia

Molecular and Cellular Neuroscience, 2022
One of the major properties of microglia is to secrete cytokines as a reaction to stress such as lipopolysaccharide (LPS) application. The mechanism of cytokine secretion from the microglia upon stress through the inflammasome-mediated release process is well studied, and the voltage-gated Kv1.3 channel is known to play an important role in this ...
Yuko, Maejima, Shoichiro, Horita, Shoko, Yokota, Megumi, Yamachi, Masaru, Shimizu, Tomoyuki, Ono, Zhiquian, Yu, Hiroaki, Tomita, Kenju, Shimomura   +8 more
openaire   +2 more sources

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density

Biochemical and Biophysical Research Communications, 2008
The inward rectifier current generated by Kir2.1 ion channel proteins is primarily responsible for the stable resting membrane potential in various excitable cell types, like neurons and myocytes. Tight regulation of Kir2.1 functioning prevents premature action potential formation and ensures optimal repolarization times.
John A, Jansen, Teun P, de Boer, Rianne, Wolswinkel, Toon A B, van Veen, Marc A, Vos, Harold V M, van Rijen, Marcel A G, van der Heyden   +6 more
openaire   +2 more sources

Abstract 1138: Impaired Flow-induced Vasodilation In Arterioles By Cholesterol-induced Suppression Of Endothelial Kir2.1

Arteriosclerosis, Thrombosis and Vascular Biology
Dyslipidemia is a critical factor in endothelial dysfunction; however, the mechanisms are still not well understood. Our studies showed that cholesterol-induced suppression of endothelial flow-sensitive Kir2.1 channels contributes significantly to the ...
S. J. Ahn, Ibra S. Fancher, Shane A Phillips, Irena A. Levitan   +3 more
semanticscholar   +1 more source