Results 181 to 190 of about 5,909 (195)

Abstract Mo086: Functional impact of phosphorylation-site mutations on PKA response of Kir2.1

Circulation Research
Background: Kir2.1 channels maintain the cardiac resting membrane potential and assist in phase 3 repolarization. PKA-mediated phosphorylation modulates Kir2.1 function, impacting heart excitability and rhythm.
Saba Munawar, Corey L. Anderson, Louise Reilly, Molly Melnick, Kyle Brown, Ying Ge, Lee L. Eckhardt   +6 more
semanticscholar   +1 more source

Abstract 1023: Cholesterol Sensitivity Of A K+ Channel, Kir2.1 Plays A Role In Weight Maintenance, Energy Distribution, And Akt-dependent Mouse Mesenteric Metabolism

Arteriosclerosis, Thrombosis and Vascular Biology
Background: Inwardly Rectifying Potassium Channel 2.1 (Kir2.1) plays a role in the maintenance of membrane potential and is strongly suppressed by membrane cholesterol and diet-induced hypercholesterolemia.
Katie M. Beverley, Sara Granados, Pingwen Xu, Irena A. Levitan   +3 more
semanticscholar   +1 more source

Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase

Biochemical and Biophysical Research Communications, 2011
The inward rectifier K(+) channel Kir2.1 participates in the maintenance of the cell membrane potential in a variety of cells including neurons and cardiac myocytes. Mutations of KCNJ2 encoding Kir2.1 underlie the Andersen-Tawil syndrome, a rare disorder clinically characterized by periodic paralysis, cardiac arrhythmia and skeletal abnormalities.
Alesutan, Ioana, Munoz, Carlos, Sopjani, Mentor, Dermaku-Sopjani, Miribane, Michael, Diana, Fraser, Scott, Kemp, Bruce, Seebohm, Guiscard, Foller, Michael, Lang, Florian   +9 more
openaire   +4 more sources

Loss of functions mutations in Kir2.1 channels

2020
Die Mutation des einwärtsgerichteten Kaliumkanal Kir2.1 führt zu einem Verlust oder Erniedrigung des Kaliumausstromes aus der Zelle. Dieser Kanal wird im Körper, vor allem in dem Herzen, dem Gehirn sowie dem Blutsystem produziert und hat eine sehr wichtige Rolle in der Repolarisation der Zelle.
openaire   +1 more source

Endocytosis of the potassium channel Kir2.1

2015
Der exakte Mechanismus, welcher die Regulation der Oberfächenexpression des Kaliumkanals Kir2.1 beschreibt, ist bisher nicht abschließend aufgeklärt. In der vorliegenden Arbeit wird gezeigt, wie die Kir2.1-Oberflächenexpression gesteuert wird, indem der Kanal durch den Clathrin-abhängigen Endozytoseweg der Zelle ...
openaire   +1 more source

Kir2.1 K+ Channels of the Gastric Parietal Cell

2002
The purpose of this article is to review the literature regarding the characteristics of the gastric parietal cell apical membrane K+ channel and provide new evidence that suggests that the inward rectifying K+ channel, Kir2.1, may be involved in K+ recycling at the apical membrane of the gastric parietal cell.
John Cuppoletti, Kirti P. Tewari, Ann M. Sherry, Danuta H. Malinowska   +3 more
openaire   +1 more source

A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation

Biochemical and Biophysical Research Communications, 2005
The inward rectifier K(+) channel Kir2.1 mediates the potassium I(K1) current in the heart. It is encoded by KCNJ2 gene that has been linked to Andersen's syndrome. Recently, strong evidences showed that Kir2.1 channels were associated with mouse atrial fibrillation (AF), therefore we hypothesized that KCNJ2 was associated with familial AF.
Xia, Min, Jin, Qingfeng, Bendahhou, Saïd, He, Yusong, Larroque, Marie-Madeleine, Chen, Yiping, Zhou, Qinshu, Yang, Yiqing, Liu, Yi, Liu, Ban, Zhu, Qian, Zhou, Yanting, Lin, Jie, Liang, Bo, Li, Li, Dong, Xiongjian, Pan, Zhiwen, Wang, Rongrong, Wan, Haiying, Qiu, Weiqin, Xu, Wenyuan, Eurlings, Petra, Barhanin, Jacques, Chen, Yihan   +23 more
openaire   +3 more sources

Endocannabinoid regulation of inward rectifier (Kir2.1) channels

Biophysical Journal, 2023
Ameneh Ahrari, Sultan Mayar, Madeleine M. Labonte, Niveny Sinniah, Mina Memarpoor-Yazdi, Nazzareno D'Avanzo   +5 more
openaire   +1 more source

Endocannabinoid regulation of Kir2.1 inward rectifier potassium channels

Biophysical Journal, 2022
Ameneh Ahrari, Sultan Mayar, Niveny Sinniah, Mina Memarpoor-Yazdi, Nazzareno D’Avanzo   +4 more
openaire   +1 more source

Elektrofyziologická charakterizace membránového kanálu Kir2.1

Tato diplomová práce se věnuje problematice elektrofyziologické charakterizace membránového kanálu Kir2.1. Vnitřně usměrňující draslíkový kanál Kir2.1 se nachází v buňkách svalových, srdečních i nervových a jeho dysfunkce způsobuje různá onemocnění. Praktická část práce je zaměřená na kultivaci buněčné linie HEK293T sloužící k transfekci plasmidu Kir2 ...
openaire   +1 more source